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J-GLOBAL ID：201702263932527832   Reference number：17A1898080

Sake lees hydrolysate protects against acetaminophen-induced hepatotoxicity via activation of the Nrf2 antioxidant pathway

酒粕の加水分解産物はNrf2抗酸化経路の活性化を経てアセトアミノフェン誘発性肝毒性を防ぐ

Author (8)： Kawakami Kayoko (School of Pharmacy, Shujitsu University) ,  Moritani Chie (School of Pharmacy, Shujitsu University) ,  Uraji Misugi (Okayama Prefectural Technology Center for Agriculture, Forestry and Fisheries, Research Institute for Biological Sciences (RIBS)) ,  Fujita Akiko (SATAKE Corporation) ,  Kawakami Koji (SATAKE Corporation) ,  Hatanaka Tadashi (Okayama Prefectural Technology Center for Agriculture, Forestry and Fisheries, Research Institute for Biological Sciences (RIBS)) ,  Suzaki Etsuko (School of Pharmacy, Shujitsu University) ,  Tsuboi Seiji (School of Pharmacy, Shujitsu University)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 61  Issue： 3  Page： 203-209(J-STAGE)  Publication year： 2017 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antipyretic analgesic ,...
Semi thesaurus term： gamma-glutamylcysteine synthetase ,...

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Author keywords (4)： sake lees hydrolysate ,  acetaminophen ,  hepatotoxicity ,  Nrf2

JST classification (1)： Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Acetaminophen

Reference (38)：

• 1 Laskin DL, Pilaro AM. Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. Toxicol Appl Pharmacol 1986; 86: 204-215.
• 2 Hazai E, Vereczkey L, Monostory K. Reduction of toxic metabolite formation of acetaminophen. Biochem Biophys Res Commun 2002; 291: 1089-1094.
• 3 Klaassen CD, Reisman SA. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol 2010; 244: 57-65.
• 4 Kawakami K, Moritani C, Uraji M, et al. Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice. J Clin Biochem Nutr 2017; 60: 115-120.
• 5 Farombi EO, Surh YJ. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 2006; 39: 479-491.

Terms in the title (8)： 酒粕 ,  分解産物 ,  NRF2 ,  酸化 ,  経路 ,  活性化 ,  アセトアミノフェン ,  肝毒性