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J-GLOBAL ID：201702264404210743   Reference number：17A0834624

Structural and conformational determinants of macrocycle cell permeability

大環状化合物の細胞透過性の構造的及び立体配座決定因子

Author (20)： OVER Bjoern (AstraZeneca R&D Gothenburg, Moelndal, SWE) ,  MATSSON Paer (Uppsala Univ., Uppsala, SWE) ,  TYRCHAN Christian (AstraZeneca R&D Gothenburg, Moelndal, SWE) ,  ARTURSSON Per (Uppsala Univ., Uppsala, SWE) ,  DOAK Bradley C (Uppsala Univ., Uppsala, SWE) ,  FOLEY Michael A (Broad Inst., Massachusetts, USA) ,  FOLEY Michael A ,  HILGENDORF Constanze (AstraZeneca R&D Gothenburg, Moelndal, SWE) ,  JOHNSTON Stephen E (Broad Inst., Massachusetts, USA) ,  LEE Maurice D, IV (Broad Inst., Massachusetts, USA) ,  LEE Maurice D, IV ,  LEWIS Richard J (AstraZeneca R&D Gothenburg, Moelndal, SWE) ,  MCCARREN Patrick (Broad Inst., Massachusetts, USA) ,  MUNCIPINTO Giovanni (Broad Inst., Massachusetts, USA) ,  MUNCIPINTO Giovanni ,  NORINDER Ulf (Swedish Toxicology Sci. Res. Center, Soedertaelje, SWE) ,  PERRY Matthew W D (AstraZeneca R&D Gothenburg, Moelndal, SWE) ,  DUVALL Jeremy R (Broad Inst., Massachusetts, USA) ,  DUVALL Jeremy R ,  KIHLBERG Jan (Uppsala Univ., Uppsala, SWE)
Material： Nature Chemical Biology  (Nat Chem Biol)
Volume： 12  Issue： 12  Page： 1065-1074  Publication year： Dec. 2016 
JST Material Number： W2213A  ISSN： 1552-4450  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *macrocyclic compound ,  steric conformation ,  *drug design ,  group (radical) ,  intramolecular interaction ,  chemical property ,  conformational analysis ,  oral absorption ,  space structure ,  stereochemistry ,  functional group ,  *Rational drug design ,  *Cell Membrane Permeability ,  Physico-chemical property

JST classification (1)： Basic biopharmacy  (GY01021U)

Terms in the title (5)： 大環状化合物 ,  細胞 ,  透過性 ,  立体配座 ,  決定因子