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J-GLOBAL ID：201702265126288866   Reference number：17A1697896

Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

脂質過酸化物のリポキシゲナーゼ介在生成はエラスチンとRSL3により誘導されるフェロトーシスを増強する

Author (9)： Shintoku Ryosuke (Secretion Biology Laboratory, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Shintoku Ryosuke (Department of Neurosurgery, Graduate School of Medicine, Gunma University, Maebashi, Japan) ,  Takigawa Yuta (Department of Laboratory Sciences, Graduate School of Health Sciences, Gunma University, Maebashi, Japan) ,  Yamada Keiichi (Department of Chemistry and Chemical Biology, Graduate School of Science and Technology, Kiryu, Japan) ,  Kubota Chisato (Secretion Biology Laboratory, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Yoshimoto Yuhei (Department of Neurosurgery, Graduate School of Medicine, Gunma University, Maebashi, Japan) ,  Takeuchi Toshiyuki (Secretion Biology Laboratory, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan) ,  Koshiishi Ichiro (Department of Laboratory Sciences, Graduate School of Health Sciences, Gunma University, Maebashi, Japan) ,  Torii Seiji (Secretion Biology Laboratory, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 11  Page： 2187-2194  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Elastin ,...
Semi thesaurus term： *lipid peroxide

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Author keywords (5)： Cell death ,  glutathione peroxidase ,  iron ,  Ras ,  reactive oxygen species

JST classification (1)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： RSL3

Reference (28)：

• Conrad M, Angeli JP, Vandenabeele P, Stockwell BR. Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2016; 15: 348-66.
• Cao JY, Dixon SJ. Mechanisms of ferroptosis. Cell Mol Life Sci 2016; 73: 2195-209.
• Dixon SJ, Lemberg KM, Lamprecht MR et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012; 149: 1060-72.
• Yang WS, SriRamaratnam R, Welsch ME et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 2014; 156: 317-31.
• Lachaier E, Louandre C, Godin C et al. Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. Anticancer Res 2014; 34: 6417-22.

Terms in the title (6)： 脂質過酸化物 ,  リポキシゲナーゼ ,  エラスチン ,  誘導 ,  フェロトーシス ,  増強