Art

J-GLOBAL ID：201702265346241418   Reference number：17A0790784

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

がんの薬剤抵抗性状態としてのまれな細胞多様性と薬剤誘導性再プログラム化

Author (17)： SHAFFER Sydney M. (Univ. Pennsylvania, Pennsylvania, USA) ,  DUNAGIN Margaret C. (Univ. Pennsylvania, Pennsylvania, USA) ,  TORBORG Stefan R. (Univ. Pennsylvania, Pennsylvania, USA) ,  TORRE Eduardo A. (Univ. Pennsylvania, Pennsylvania, USA) ,  RAJ Arjun (Univ. Pennsylvania, Pennsylvania, USA) ,  EMERT Benjamin (Univ. Pennsylvania, Pennsylvania, USA) ,  EGGAN Elliott (Univ. Pennsylvania, Pennsylvania, USA) ,  ANASTOPOULOS Ioannis N. (Univ. Pennsylvania, Pennsylvania, USA) ,  NATHANSON Katherine L. (Univ. Pennsylvania, Pennsylvania, USA) ,  KREPLER Clemens (Wistar Inst., Pennsylvania, USA) ,  BEQIRI Marilda (Wistar Inst., Pennsylvania, USA) ,  SPROESSER Katrin (Wistar Inst., Pennsylvania, USA) ,  BRAFFORD Patricia A. (Wistar Inst., Pennsylvania, USA) ,  XIAO Min (Wistar Inst., Pennsylvania, USA) ,  HERLYN Meenhard (Wistar Inst., Pennsylvania, USA) ,  VARGAS-GARCIA Cesar A. (Univ. Delaware, Delaware, USA) ,  SINGH Abhyudai (Univ. Delaware, Delaware, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 546  Issue： 7658  Page： 431-435  Publication year： Jun. 15, 2017 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *tumor cell ,  *Drug Resistance ,  gene ,  gene expression ,  acquisition ,  *melanoma cell ,  marker gene ,  evolution of resistance ,  single cell ,  *Drug Resistance, Neoplasm ,  molecular genetic phenomenon ,  enzyme inhibitor ,  molecular targeting drug
Semi thesaurus term： *Drug Resistance, Neoplasm

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Vemurafenib

Terms in the title (5)： がん ,  薬剤抵抗性 ,  細胞 ,  多様性 ,  薬剤