Art

J-GLOBAL ID：201702265541317379   Reference number：17A1444165

A fusion protein of interleukin-4 and interleukin-10 protects against blood-induced cartilage damage in vitro and in vivo

インターロイキン-4とインターロイキン-10の融合蛋白質はin vitroおよびin vivoでの血液誘発軟骨損傷に対して保護作用を示す【Powered by NICT】

Author (12)： van Vulpen L. F. D. (Van Creveldkliniek, University Medical Center Utrecht, Utrecht, the Netherlands) ,  van Vulpen L. F. D. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Popov-Celeketic J. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  van Meegeren M. E. R. (Van Creveldkliniek, University Medical Center Utrecht, Utrecht, the Netherlands) ,  van Meegeren M. E. R. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Coeleveld K. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  van Laar J. M. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Hack C. E. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Hack C. E. (Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Schutgens R. E. G. (Van Creveldkliniek, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Mastbergen S. C. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands) ,  Lafeber F. P. J. G. (Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands)
Material： Journal of Thrombosis and Haemostasis  (J Thromb Haemost)
Volume： 15  Issue： 9  Page： 1788-1798  Publication year： 2017 
JST Material Number： W1621A  ISSN： 1538-7933  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Essentials Targeted treatment ...

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Thesaurus term： *in vitro experiment ,  macrophage ,  histochemistry ,  human ,  *Cartilage ,  interleukin 10 ,  *protective action ,  clinical trial ,  interleukin 6 ,  interleukin 4 ,  *fusion protein ,  monocyte ,  synovitis ,  hemophilia
Semi thesaurus term： *軟骨傷害 , 【Automatic Indexing@JST】

Author keywords (6)： hemarthrosis ,  hemophilia A ,  investigational ,  joint diseases ,  synovitis ,  therapies

JST classification (3)： Gene manipulation  (EC02050B) ,  Enzyme in general  (EB09010D) ,  Gene expression  (EC02040Q)

Terms in the title (7)： インターロイキン-4 ,  インターロイキン-10 ,  融合蛋白質 ,  血液 ,  誘発 ,  軟骨損傷 ,  保護作用