Art

J-GLOBAL ID：201702266566753556   Reference number：17A0791215

Evaluating the efficacy of epinastine ophthalmic solution using a conjunctivitis allergen challenge model in patients with birch pollen allergic conjunctivitis

カバノキ花粉アレルギー性結膜炎患者において結膜アレルゲン曝露モデルを用いてエピナスチンオフタルム酸溶液点眼液の有効性を評価する

Author (5)： Tagawa Yoshiaki (Department of Ophthalmology, Hokkaido University Graduate School of Medicine) ,  Namba Kenichi (Department of Ophthalmology, Hokkaido University Graduate School of Medicine) ,  Nakazono Yumi (Global Research & Development Center, Santen Pharmaceutical Co., Ltd.) ,  Iwata Daiju (Department of Ophthalmology, Hokkaido University Graduate School of Medicine) ,  Ishida Susumu (Department of Ophthalmology, Hokkaido University Graduate School of Medicine)
Material： Allergology International  (Allergol Int)
Volume： 66  Issue： 2  Page： 338-343(J-STAGE)  Publication year： 2017 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Betulaceae ,...
Semi thesaurus term： Birch ,...

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Author keywords (5)： Allergic conjunctivitis ,  Birch pollen ,  Conjunctival allergen challenge ,  Histamine 1 (H1) receptor antagonist ,  Tear histamine level

JST classification (2)： Clinical application of drugs acting on sensory organs  (GW04070V) ,  Drug therapy(=pharmacotherapy)for eye diseases  (GP05020E)

Substance index (2)： Epinastine ,  Ophthalmic acid

Reference (21)：

• 1. Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, et al. Japanese guideline for allergic conjunctival diseases. Allergol Int 2011;60:191-203.
• 2. Abe Y, Yanai M, Nagato T, Ogino T, Harabuchi Y. [Clinical analysis of allergic rhinitis (pollinosis) in Hokkaido]. [Jpn J Allergol] 2005;54:59-67 (in Japanese).
• 3. D'Amato G, Spieksma FT, Liccardi G, Jäger S, Russo M, Kontou-Fili K, et al. Pollen-related allergy in Europe. Allergy 1998;53:567-78.
• 4. Fügner A, Bechtel WD, Kuhn FJ, Mierau J. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung 1988;38:1446-53.
• 5. Tasaka K, Akagi M, Izushi K, Aoki I. Antiallergic effect of epinastine: the elucidation of the mechanism. Pharmacometrics 1990;39:365-73.

Terms in the title (14)： カバノキ ,  花粉 ,  アレルギー性結膜炎 ,  患者 ,  結膜 ,  アレルゲン ,  曝露 ,  モデル ,  エピナスチン ,  オフタルム酸 ,  溶液 ,  点眼液 ,  有効性 ,  評価