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J-GLOBAL ID：201702267985190245   Reference number：17A1566908

Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

多能性幹細胞からの進化的に異なる転写とシグナル伝達プログラムヒト生殖細胞系統特異化を駆動する【Powered by NICT】

Author (28)： Kojima Yoji (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kojima Yoji (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kojima Yoji (Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kojima Yoji (Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Sasaki Kotaro (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Sasaki Kotaro (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yokobayashi Shihori (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yokobayashi Shihori (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yokobayashi Shihori (Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Sakai Yoshitake (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Sakai Yoshitake (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nakamura Tomonori (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nakamura Tomonori (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yabuta Yukihiro (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yabuta Yukihiro (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nakaki Fumio (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nakaki Fumio (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nagaoka So (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nagaoka So (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Woltjen Knut (Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Hotta Akitsu (Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Yamamoto Takuya (Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Yamamoto Takuya (Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan) ,  Yamamoto Takuya (AMED-CREST, AMED, 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan) ,  Saitou Mitinori (Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Saitou Mitinori (JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Saitou Mitinori (Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan) ,  Saitou Mitinori (Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan)
Material： Cell Stem Cell
Volume： 21  Issue： 4  Page： 517-532.e5  Publication year： 2017 
JST Material Number： W3106A  ISSN： 1934-5909  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Germline specification underli...

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Thesaurus term： *human ,  induced pluripotent stem cell ,  *versatility ,  modeling ,  *pluripotent stem cell ,  interaction ,  mesoderm ,  transcription factor ,  *reproductive cell ,  duration time ,  differentiation (biology) ,  gonocyte ,  signal transduction pathway
Semi thesaurus term： 伝達経路 ,  胚盤胞移植 , 【Automatic Indexing@JST】

Author keywords (10)： human development ,  primordial germ cells ,  specification ,  human iPSCs ,  transcription factors ,  pluripotency ,  cynomolgus monkeys ,  EOMES ,  SOX17 ,  TFAP2C

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (7)： 多能性幹細胞 ,  進化 ,  転写 ,  シグナル伝達 ,  ヒト ,  生殖 ,  細胞系統