Art
J-GLOBAL ID：201702268308663933   Reference number：17A1783171

Novel p-carborane-containing multitarget anticancer agents inspired by the metabolism of 17β-estradiol

17β-エストラジオールの代謝に示唆された新しいpカルボランを含む多標的抗腫瘍薬【Powered by NICT】
Author (3)：
Kaise Asako

About Kaise Asako

(Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan)

About Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

, 
Ohta Kiminori

About Ohta Kiminori

(Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan)

About Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

, 
Endo Yasuyuki

About Endo Yasuyuki

(Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan)

About Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan


Material：
Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)

About Bioorganic & Medicinal Chemistry


Volume： 25  Issue： 24  Page： 6371-6378  Publication year： Dec. 15, 2017 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
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The female hormone 17 β-estrad...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*carboranes

About carboranes

, 
inhibition of multiplication

About inhibition of multiplication

, 
arylsulfatase

About arylsulfatase

, 
estrogen receptor

About estrogen receptor

, 
*antitumor action

About antitumor action

, 
enzyme inhibition

About enzyme inhibition

, 
antitumor drug

About antitumor drug

, 
MCF7 cell

About MCF7 cell

, 
tumor cell

About tumor cell

, 
cultured cell

About cultured cell

, 
affinity

About affinity

, 
*Metabolism

About Metabolism

, 
molecular targeting drug

About molecular targeting drug

, 
LNCaP cell

About LNCaP cell

, 
MDA-MB-453 cell

About MDA-MB-453 cell

, 
Estrogen Receptor alpha

About Estrogen Receptor alpha

, 
binding affinity

About binding affinity

, 
Steryl-Sulfatase

About Steryl-Sulfatase

, 
steroid

About steroid

, 
estrogen

About estrogen

, 
steroid hormone

About steroid hormone

, 
phenolic compound

About phenolic compound

, 
diol

About diol


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*p-カルボラン誘導体

About p-カルボラン誘導体

, 
steroid sulfatase

About steroid sulfatase

, 
Tubulin Modulators

About Tubulin Modulators

, 
多標的薬

About 多標的薬


Author keywords (5)：
Carborane

About Carborane

, 
2-Methoxyestdadiol

About 2-Methoxyestdadiol

, 
Anti-tumor activity

About Anti-tumor activity

, 
Steroid sulfatase inhibition

About Steroid sulfatase inhibition

, 
Tubulin polymerization inhibition

About Tubulin polymerization inhibition

JST classification (7)：
JST classification
Category name(code) classified by JST.
Organoboron compounds 
(CF08020R)

About Organoboron compounds

,  Aromatic monocyclic compounds in general 
(CF05010L)

About Aromatic monocyclic compounds in general

,  Basic oncology in general 
(GE02010R)

About Basic oncology in general

,  Structure-activity relationship of drugs 
(GV01050B)

About Structure-activity relationship of drugs

,  Basic research of antitumor(=antineoplastic)drugs 
(GW16010A)

About Basic research of antitumor(=antineoplastic)drugs

,  Basic research of enzyme preparations and enzyme inhibitor preparations 
(GW21010W)

About Basic research of enzyme preparations and enzyme inhibitor preparations

,  Synthesis of drugs 
(GV01030F)

About Synthesis of drugs

Substance index (2)：
Substance index
Chemical Substance indexed to the Article.
Estradiol

About Estradiol

, 
2-Methoxyestradiol

About 2-Methoxyestradiol

Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
17β-エストラジオール

About 17β-エストラジオール

, 
代謝

About 代謝

, 
カルボラン

About カルボラン

, 
標的

About 標的

, 
抗腫瘍薬

About 抗腫瘍薬


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