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J-GLOBAL ID：201702269175924073   Reference number：17A1161443

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

筋萎縮性側索硬化症における病理学的オリゴマ化へのCu/Zn-スーパーオキシドジスムターゼの誤って折り畳まれた二量体【Powered by NICT】

Author (10)： Anzai Itsuki (Department of Chemistry, Keio University, Yokohama, 223-8522, Japan) ,  Tokuda Eiichi (Department of Chemistry, Keio University, Yokohama, 223-8522, Japan) ,  Mukaiyama Atsushi (Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science, NINS, Okazaki, 444-8585, Japan) ,  Mukaiyama Atsushi (Department of Functional Molecular Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, 444-8585, Japan) ,  Akiyama Shuji (Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science, NINS, Okazaki, 444-8585, Japan) ,  Akiyama Shuji (Department of Functional Molecular Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, 444-8585, Japan) ,  Endo Fumito (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan) ,  Yamanaka Koji (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464-8601, Japan) ,  Misawa Hidemi (Division of Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, 105-8512, Japan) ,  Furukawa Yoshiaki (Department of Chemistry, Keio University, Yokohama, 223-8522, Japan)
Material： Protein Science
Volume： 26  Issue： 3  Page： 484-496  Publication year： 2017 
JST Material Number： W2730A  ISSN： 0961-8368  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Misfolding of mutant Cu/Zn-sup...

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Thesaurus term： spinal cord ,  *oligomer ,  *superoxide dismutase ,  *pathological state ,  *amyotrophic lateral sclerosis ,  protein ,  *dimer ,  secondary structure ,  steric conformation ,  variation(biology) ,  disulfide bond ,  pathogenicity ,  *oligomerization
Semi thesaurus term： スーパーオキシドジスムターゼ1 ,  Cu/Znスーパーオキシドジスムターゼ , 【Automatic Indexing@JST】

Author keywords (7)： Cu/Zn-superoxide dismutase ,  SOD1 ,  amyotrophic lateral sclerosis ,  ALS ,  protein misfolding ,  circular dichroism spectroscopy ,  small-angle X-ray scattering

JST classification (2)： Basic neurology  (GN01020W) ,  Enzyme in general  (EB09010D)

Terms in the title (7)： 筋萎縮性側索硬化症 ,  病理学 ,  オリゴマ化 ,  Cu ,  Zn ,  スーパーオキシドジスムターゼ ,  二量体