Art

J-GLOBAL ID：201702269767630573   Reference number：17A0085096

Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection

C型肝炎ウイルス遺伝子型1b感染症の患者における自然発生ソホスブビル耐性関連変異体の保有率と特性

Author (23)： Ito Jun (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Suda Goki (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Yamamoto Yoshiya (Department of Gastroenterology, Hakodate City General Hospital, Hakodate) ,  Nagasaka Atsushi (Department of Gastroenterology, Sapporo City General Hospital, Sapporo) ,  Furuya Ken (Department of Gastroenterology, JCHO Hokkaido Hospital, Sapporo) ,  Kumagai Kenichi (Department of Gastroenterology, Hakodate Medical Association Hospital, Hakodate) ,  Kikuchi Hideaki (Department of Gastroenterology, Obihiro-Kosei General Hospital, Obihiro) ,  Miyagishima Takuto (Department of Internal Medicine and Gastroenterology, Kushiro Rosai Hospital, Kushiro) ,  Kobayashi Tomoe (Department of Gastroenterology, Tomakomai City Hospital, Tomakomai, Japan) ,  Kimura Megumi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Yamasaki Kazushi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Umemura Machiko (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Izumi Takaaki (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Tsunematsu Seiji (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Sato Fumiyuki (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Tsukuda Yoko (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Terashita Katsumi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Nakai Masato (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Sho Takuya (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Natsuizaka Mitsuteru (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Morikawa Kenichi (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Ogawa Koji (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo) ,  Sakamoto Naoya (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo)
Material： Hepatology Research  (Hepatol Res)
Volume： 46  Issue： 13  Page： 1294-1303  Publication year： Dec. 2016 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： NS5B ,...

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Author keywords (3)： direct-acting antiviral ,  hepatitis C virus ,  resistance-associated-variant

JST classification (2)： Clinical application of antiviral drugs  (GW17050Z) ,  Treatment for infectious diseases,parasitic diseases.  (GD01030D)

Substance index (2)： Sofosbuvir ,  Ribavirin

Reference (41)：

• Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013; 57: 1333-42.
• Seeff LB. Natural history of chronic hepatitis C. Hepatology 2002; 36: S35-46.
• Sakamoto N, Watanabe M. New therapeutic approaches to hepatitis C virus. J Gastroenterol 2009; 44: 643-9.
• Izumi N, Hayashi N, Kumada H et al. Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studies. J Gastroenterol 2014; 49: 941-53.
• Kumada H, Hayashi N, Izumi N et al. Simeprevir (TMC435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis C virus infection: the CONCERTO-4 study. Hepatol Res 2015; 45: 501-13.

Terms in the title (9)： C型肝炎ウイルス ,  遺伝子型1b ,  感染症 ,  患者 ,  自然発生 ,  ソホスブビル ,  耐性 ,  変異体 ,  保有率