Art

J-GLOBAL ID：201702269788855390   Reference number：17A0084196

Structure and Engineering of Francisella novicida Cas9

Francisella novicida細菌(野兎病亜種菌)のCas9の構造と工学

Author (26)： Hirano Hisato (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Gootenberg Jonathan S. (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Gootenberg Jonathan S. (McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Gootenberg Jonathan S. (Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Gootenberg Jonathan S. (Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Gootenberg Jonathan S. (Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Horii Takuro (Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan) ,  Abudayyeh Omar O. (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Abudayyeh Omar O. (McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Abudayyeh Omar O. (Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Abudayyeh Omar O. (Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Kimura Mika (Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan) ,  Hsu Patrick D. (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Hsu Patrick D. (McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Hsu Patrick D. (Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Hsu Patrick D. (Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Nakane Takanori (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Ishitani Ryuichiro (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Hatada Izuho (Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan) ,  Zhang Feng (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Zhang Feng (McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Zhang Feng (Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Zhang Feng (Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Nishimasu Hiroshi (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Nishimasu Hiroshi (JST, PRESTO, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan) ,  Nureki Osamu (Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 164  Issue： 5  Page： 950-961  Publication year： Feb. 25, 2016 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Francisella ,  *endonuclease ,  *protein ,  crystal structure ,  gene expression ,  immunity ,  nucleotide sequence ,  ribonucleoprotein ,  mutant
Semi thesaurus term： *CRISPR associated protein 9 ,  CRISPR-Cas Systems ,  Francisella novicida

JST classification (1)： Proteins and peptides in general  (EB03010N)

Terms in the title (6)： Francisella ,  細菌 ,  野兎病 ,  種菌 ,  Cas9 ,  工学