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J-GLOBAL ID：201702271206450735   Reference number：17A1446726

Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects

健常日本人被験者におけるアスピリンとの併用で使用されるプラスグレルの血小板凝集抑制効果と薬物動力学【Powered by NICT】

Author (6)： Umemura Kazuo (Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu-shi, Shizuoka, Japan) ,  Ikeda Yasuhiko (Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu-shi, Shizuoka, Japan) ,  Ikeda Yasuhiko (Shin-nakagawa Hospital, Yokohama-shi, Kanagawa, Japan) ,  Matsushima Nobuko (Translational Medicine and Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd, Shinagawa-ku, Tokyo, Japan) ,  Matsushima Nobuko (Clinical Pharmacology Department, Janssen Pharmaceutical K.K. , Chiyoda-ku, Tokyo, Japan) ,  Kondo Kazunao (Department of Pharmacology, Fujita Health University School of Medicine, Toyoake-shi, Aichi, Japan)
Material： Clinical Pharmacology in Drug Development
Volume： 6  Issue： 4  Page： 398-407  Publication year： 2017 
JST Material Number： W2780A  ISSN： 2160-7648  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： We evaluated the pharmacokinet...

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Thesaurus term： pharmacodynamics ,  plasma concentration ,  *platelet aggregation ,  placebo ,  single administration ,  repeated administration ,  administration(biology) ,  *pharmacokinetics ,  diagnostic drug ,  purine nucleoside ,  ribonucleoside ,  fatty acid ,  aromatic carboxylic acid ,  phenolic compound ,  carboxylate(ester) ,  hydroxy acid
Semi thesaurus term： 有害事象 ,  抗血小板作用 ,  活性代謝物 ,  *被験者 ,  *日本人 , 【Automatic Indexing@JST】

Author keywords (5)： aspirin ,  healthy Japanese subjects ,  inhibition of platelet aggregation ,  prasugrel ,  pharmacokinetics

JST classification (1)： Clinical biopharmacy  (GY01022L)

Substance index (2)： Adenosine ,  Aspirin

Terms in the title (8)： 日本人 ,  被験者 ,  アスピリン ,  併用 ,  プラスグレル ,  血小板凝集 ,  抑制効果 ,  薬物動力学