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J-GLOBAL ID：201702271965026142   Reference number：17A0865455

CPT11 prevents virus replication in JCI cells persistently infected with JC polyomavirus

CPT11はJCポリオーマウイルスが持続性感染したJCI細胞でウイルス複製を阻止する

Author (7)： Nukuzuma Souichi (Department of Infectious Diseases, Kobe Institute of Health, 4-6-5, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan) ,  Nukuzuma Chiyoko (Thermocell, Shinagawa-ku, Tokyo 141-0022, Japan) ,  Kameoka Masanori (Department of International Health, Kobe University Graduate School of Health Sciences, Suma-ku, Kobe 615-0124, Japan) ,  Sugiura Shigeki (Medical Genetics Research Center, Nara Medical University, Kashihara, Nara 634-8521, Japan) ,  Nakamichi Kazuo (Department of Virology 1, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo 162-8640, Japan) ,  Tasaki Takafumi (Divison of Protein Regulation Research, Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan) ,  Takegami Tsutomu (Division of Molecular Oncology and Virology, Medical Research Institute, Kanazawa Medical University, Ishikawa, 920-0293, Japan)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 61  Issue： 6  Page： 232-238  Publication year： Jun. 2017 
JST Material Number： W1957A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,...
Semi thesaurus term： JCI細胞 ,...

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Author keywords (4)： 7-ethy-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin ,  IMR-32 ,  JCI ,  JC polyomavirus

JST classification (3)： Physiology and pathogenicity of virus infection  (EG04042Y) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antiviral drugs  (GW17040O)

Substance index (3)： CPT-11 ,  β-Lapachone ,  Topotecan

Reference (24)：

• Major E.O., Amemiya K., Tornatore C.S., Houff S.A., Berger J.R. (1992) Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev 5:49-73.
• Ferenczy M.W., Marshall L.J., Nelson C.D.S., Atwood W.J., Nath A., Khalili K., Major E.O. (2012) Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev 25: 471-506.
• Bendixen C., Thomsen B., Alsner J., Westergaard O. (1990) Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcription. Biochemistry 29: 5613-9.
• Hertzberg R.P., Caranfa M.J., Hecht S.M. (1989) On the mechanism of topoisomerase I inhibitor by camptothecin: evidence for binding to an enzyme-DNA complex. Biochemistry 28: 4629-38.
• Pommier Y. (2006) Topoisomerase I inhibitors: Camptothecins and beyond. Nat Rev Cancer 6: 789-802.

Terms in the title (6)： ポリオーマウイルス ,  持続性感染 ,  JCI ,  細胞 ,  ウイルス複製 ,  阻止