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J-GLOBAL ID：201702273100328790   Reference number：17A0814164

Enhanced in-cell folding of reversibly cationized transcription factor using amphipathic peptide

両親媒性ペプチドを用いた可逆カチオン化転写因子の細胞内フォールディングの強化

Author (8)： Futami Midori (Department of Biomedical Engineering, Faculty of Engineering, Okayama University of Science, Okayama 700-0005, Japan) ,  Nakano Tomoki (Department of Biomedical Engineering, Faculty of Engineering, Okayama University of Science, Okayama 700-0005, Japan) ,  Yasunaga Mayu (Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Kagawa 761-0395, Japan) ,  Makihara Masahiro (Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan) ,  Asama Takashi (Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan) ,  Hagihara Yoshihisa (Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan) ,  Nakajima Yoshihiro (Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Kagawa 761-0395, Japan) ,  Futami Junichiro (Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 123  Issue： 4  Page： 419-424  Publication year： Apr. 2017 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： amphiphilic ,...
Semi thesaurus term： cationization ,...

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Author keywords (5)： Key words Protein transduction ,  Cell-permeable peptide ,  In-cell folding ,  Amphipathic peptide ,  Chemical modification

JST classification (2)： Gene expression  (EC02040Q) ,  Proteins and peptides in general  (EB03010N)

Reference (32)：

• Futami, J., Maeda, T., Kitazoe, M., Nukui, E., Tada, H., Seno, M., Kosaka, M., and Yamada, H.: Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups, Biochemistry, 40, 7518-7524 (2001).
• Futami, J., Kitazoe, M., Maeda, T., Nukui, E., Sakaguchi, M., Kosaka, J., Miyazaki, M., Kosaka, M., Tada, H., Seno, M., and other 4 authors: Intracellular delivery of proteins into mammalian living cells by poly-ethylenimine-cationization, J. Biosci. Bioeng., 99, 95-103 (2005).
• Kitazoe, M., Murata, H., Futami, J., Maeda, T., Sakaguchi, M., Miyazaki, M., Kosaka, M., Tada, H., Seno, M., Huh, N., and other 4 authors: Protein transduction assisted by polyethylenimine-cationized carrier proteins, J. Biochem., 137, 693-701 (2005).
• Murata, H., Sakaguchi, M., Futami, J., Kitazoe, M., Maeda, T., Doura, H., Kosaka, M., Tada, H., Seno, M., Huh, N., and Yamada, H.: Denatured and reversibly cationized p53 readily enters cells and simultaneously folds to the functional protein in the cells, Biochemistry, 45, 6124-6132 (2006).
• Futami, J., Kitazoe, M., Murata, H., and Yamada, H.: Exploiting protein cationization techniques in future drug development, Expert Opin. Drug Discov., 2, 261-269 (2007).

Terms in the title (6)： 両親媒性 ,  ペプチド ,  カチオン化 ,  転写因子 ,  フォールディング ,  強化