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J-GLOBAL ID：201702273377542222   Reference number：17A0861554

Radiosensitizing Effect of P2X7 Receptor Antagonist on Melanoma in Vitro and in Vivo

in vitroおよびin vivoでのメラノーマに対するP2X7受容体拮抗薬の放射線感作作用

Author (10)： Tanamachi Keisuke (Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Tanamachi Keisuke (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Nishino Keisuke (Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Nishino Keisuke (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Mori Natsuki (Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Mori Natsuki (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Suzuki Toshihiro (Research Institute for Biomedical Sciences, Tokyo University of Science) ,  Tanuma Sei-ichi (Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  Abe Ryo (Research Institute for Biomedical Sciences, Tokyo University of Science) ,  Tsukimoto Mitsutoshi (Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 6  Page： 878-887(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *melanoma ,...
Semi thesaurus term： P2X7 receptor ,...

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Author keywords (10)： γ-ray ,  radiosensitizer ,  DNA repair ,  P2X7 receptor ,  melanoma ,  γ-ray ,  radiosensitizer ,  DNA repair ,  P2X7 receptor ,  melanoma

JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic oncology in general  (GE02010R) ,  Skin tumors(=neoplasms)  (GF04000X)

Substance index (1)： Coomassie Brilliant Blue G-250

Reference (49)：

• 1) Satyamoorthy K, Chehab NH, Waterman MJ, Lien MC, El-Deiry WS, Herlyn M, Halazonetis TD. Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells. Cell Growth Differ., 11, 467-474 (2000).
• 2) Hamada N, Maeda M, Otsuka K, Tomita M. Signaling pathways underpinning the manifestations of ionizing radiation-induced bystander effects. Curr. Mol. Pharmacol., 4, 79-95 (2011).
• 3) Tsukimoto M. Purinergic signaling is a novel mechanism of the cellular response to ionizing radiation. Biol. Pharm. Bull., 38, 951-959 (2015).
• 4) Ohshima Y, Tsukimoto M, Takenouchi T, Harada H, Suzuki A, Sato M, Kitani H, Kojima S. γ-Irradiation induces P2X7 receptor-dependent ATP release from B16 melanoma cells. Biochim. Biophys. Acta, 1800, 40-46 (2010).
• 5) Ide S, Nishimaki N, Tsukimoto M, Kojima S. Purine receptor P2Y6 mediates cellular response to gamma-ray-induced DNA damage. J. Toxicol. Sci., 39, 15-23 (2014).

Terms in the title (5)： メラノーマ ,  P2X7受容体 ,  拮抗薬 ,  放射線 ,  感作