Art

J-GLOBAL ID：201702274998466817   Reference number：17A1707690

Evaluation of antiviral activity of piperazine against Chikungunya virus targeting hydrophobic pocket of alphavirus capsid protein

アルファウイルスカプシド蛋白質の疎水性ポケットを標的としたチクングニアウイルスに対するピペラジンの抗ウイルス活性の評価【Powered by NICT】

Author (9)： Aggarwal Megha (Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India) ,  Kaur Ramanjit (Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India) ,  Saha Amrita (Division of Virology, Defence Research and Development Establishment, Gwalior 474002, India) ,  Mudgal Rajat (Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India) ,  Yadav Ravi (Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India) ,  Dash Paban Kumar (Division of Virology, Defence Research and Development Establishment, Gwalior 474002, India) ,  Parida Manmohan (Division of Virology, Defence Research and Development Establishment, Gwalior 474002, India) ,  Kumar Pravindra (Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India) ,  Tomar Shailly (Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India)
Material： Antiviral Research  (Antivir Res)
Volume： 146  Page： 102-111  Publication year： 2017 
JST Material Number： D0654B  ISSN： 0166-3542  CODEN： ARSRDR  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Small heterocyclic molecules s...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A1707690&from=J-GLOBAL&jstjournalNo=D0654B") }}

Thesaurus term： *Alphavirus ,  *hydrophobic ,  conformational transition ,  *Viruses ,  *antiviral action ,  drug therapy ,  affinity ,  antiviral drug ,  complex (substance) ,  fluorescent antibody technique ,  crystal structure ,  *Chikungunya virus ,  *Capsid Proteins ,  *microorganism ,  bioassay ,  nitrogen heterocyclic compound
Semi thesaurus term： 分子ドッキング , 【Automatic Indexing@JST】

Author keywords (6)： Capsid protein ,  Alphavirus ,  Piperazine ,  Crystal structure ,  Hydrophobic pocket ,  Antiviral agent

JST classification (1)： Basic research of antiviral drugs  (GW17040O)

Substance index (1)： Piperazine

Terms in the title (8)： アルファウイルス ,  カプシド蛋白質 ,  疎水性 ,  標的 ,  チクングニアウイルス ,  ピペラジン ,  抗ウイルス活性 ,  評価