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J-GLOBAL ID：201702275182169075   Reference number：17A0687840

Senescent cell ablation and senolytic drugs

細胞老化研究の新展開-老化細胞は新たな創薬標的となるか-

Author (3)： MIKAWA RYUTA (国立長寿医療研究セ 研) ,  SUGIMOTO MASATAKA (国立長寿医療研究セ 研) ,  SUGIMOTO MASATAKA (名古屋大 大学院医学研究科 老化基礎科学)
Material： 基礎老化研究  (Biomedical Gerontology)
Volume： 41  Issue： 2  Page： 31-37  Publication year： May. 31, 2017 
JST Material Number： Y0748A  ISSN： 0912-8921  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *cell aging ,...
Semi thesaurus term： Drug target

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JST classification (4)： Cell physiology in general  (EF02010S) ,  Aging and death  (EJ16040S) ,  Gene manipulation  (EC02050B) ,  Gene expression  (EC02040Q)

Reference (39)：

• Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp.Cell Res. 25 : 585-621, 1961.
• Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 : 593-602, 1997.
• Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc.Natl.Acad.Sci.U.S.A. 92 : 9363-9367, 1995.
• Coppe JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS.Biol. 6 : 2853-2868, 2008.
• Munoz-Espin D, Serrano M, Cellular senescence: from physiology to pathology. Nature reviews. Molecular cell biology 15 : 482-496, 2014.

Terms in the title (5)： 細胞老化 ,  研究 ,  展開 ,  老化細胞 ,  創薬標的