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J-GLOBAL ID：201702275540448504   Reference number：17A1114608

Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression

パールカンはSox9遺伝子発現の調節を介して滑膜間葉系細胞の軟骨形成分化に必要である【Powered by NICT】

Author (13)： Sadatsuki Ryo (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan) ,  Kaneko Haruka (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan) ,  Kinoshita Mayuko (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan) ,  Futami Ippei (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan) ,  Nonaka Risa (Research Institute for Disease of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Culley Kirsty L. (Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York) ,  Otero Miguel (Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York) ,  Hada Shinnosuke (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan) ,  Goldring Mary B. (Laboratory for Cartilage Biology, Research Division, The Hospital for Special Surgery, Weill Cornell Medical College, New York) ,  Yamada Yoshihiko (Laboratory of Cell and Development Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland) ,  Kaneko Kazuo (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan) ,  Arikawa-Hirasawa Eri (Research Institute for Disease of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Ishijima Muneaki (Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan)
Material： Journal of Orthopaedic Research
Volume： 35  Issue： 4  Page： 837-846  Publication year： 2017 
JST Material Number： W2653A  ISSN： 0736-0266  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： We previously reported that pe...

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Thesaurus term： mRNA ,  *synovial membrane ,  *cartilage ,  culture(biology) ,  *osteogenesis ,  *gene expression ,  *differentiation(biology) ,  PPAR gamma ,  lipogenesis ,  protein
Semi thesaurus term： Runx2 ,  *軟骨形成 ,  *間葉細胞 ,  *SOX9転写因子 ,  *パールカン , 【Automatic Indexing@JST】

Author keywords (5)： perlecan ,  synovial mesenchymal cell ,  Sox9 ,  chondrogenic differentiation ,  osteophyte

JST classification (5)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Clinical neurology in general  (GN01030H) ,  Musculoskeletal diseases  (GG03000T) ,  Congenital diseases,deformities in general.  (GD03010V)

Terms in the title (8)： パールカン ,  Sox9遺伝子 ,  発現 ,  調節 ,  滑膜 ,  間葉系細胞 ,  軟骨形成 ,  分化