Art

J-GLOBAL ID：201702276211065334   Reference number：17A1089772

T-5224, a selective inhibitor of c-Fos/ activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model

c-Fos/活性化因子蛋白質-1の選択的阻害剤,T-5224は致死的なリポ多糖類誘導急性腎障害モデルの血清高移動度グループボックス-1阻害により生存を改善する

Author (7)： ISHIDA Mari (Hyogo Rehabilitation Centre Central Hospital, Hyogo, JPN) ,  UEKI Masaaki (Nishiwaki Municipal Hospital, Hyogo, JPN) ,  UEKI Masaaki (Kobe Univ. Hospital, Hyogo, JPN) ,  MORISHITA Jun (Higashiosaka City General Hospital, Osaka, JPN) ,  UENO Masaki (Kagawa Univ., Kagawa, JPN) ,  SHIOZAWA Shunichi (Kyushu Univ. Beppu Hospital, Oita, JPN) ,  MAEKAWA Nobuhiro (Nishiwaki Municipal Hospital, Hyogo, JPN)
Material： Journal of Intensive Care (Web)
Volume： 3  Issue： Nov  Page： 3:49 (WEB ONLY)  Publication year： Nov. 2015 
JST Material Number： U1116A  ISSN： 2052-0492  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Septicemia ,...
Semi thesaurus term： *Acute nephritis

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A1089772&from=J-GLOBAL&jstjournalNo=U1116A") }}

JST classification (2)： Basic medicine on urogenital system  (GM01020T) ,  Basic research of drugs acting on urinary system  (GW11010R)

Substance index (1)： T5224

Reference (25)：

• Gustot T. Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response. Curr Opin Crit Care. 2011;17:153-59.
• Hocherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol. 2010;298:F196-204.
• Doi K, Leelahavanichkul A, Yuen PS, Star RA. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest. 2009;119:2868-78.
• Yang H, Tracey KJ. Targeting HMGB1 in inflammation. Biochim Biophys Acta. 2010;1799:149-56.
• Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science. 1999;285:248-51.

Terms in the title (13)： c-Fos ,  蛋白質 ,  阻害剤 ,  リポ多糖類 ,  誘導 ,  急性腎障害 ,  モデル ,  血清 ,  高移動度 ,  グループ ,  ボックス ,  阻害 ,  生存