Art

J-GLOBAL ID：201702276250095630   Reference number：17A0500556

Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer

新規吸収促進剤としてのペグ化ポリ-L-オルニチン複合体の調製と評価

Author (8)： Kamiya Yusuke (Faculty of Pharmaceutical Sciences, Josai University) ,  Yamaki Tsutomu (Faculty of Pharmaceutical Sciences, Josai University) ,  Uchida Masaki (Faculty of Pharmaceutical Sciences, Josai University) ,  Hatanaka Tomomi (Tokai University School of Medicine) ,  Kimura Mitsutoshi (Faculty of Pharmaceutical Sciences, Josai University) ,  Ogihara Masahiko (Faculty of Pharmaceutical Sciences, Josai University) ,  Morimoto Yasunori (Faculty of Pharmaceutical Sciences, Josai University) ,  Natsume Hideshi (Faculty of Pharmaceutical Sciences, Josai University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 2  Page： 205-211(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *absorption promoter ,...
Semi thesaurus term： polycation ,...

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Author keywords (6)： poly-L-ornithine (PLO) ,  polyethylene glycol (PEG) ,  permeation enhancer ,  poly-L-ornithine (PLO) ,  polyethylene glycol (PEG) ,  permeation enhancer

JST classification (2)： Basic otorhinolaryngology  (GQ01020F) ,  Basic biopharmacy  (GY01021U)

Reference (23)：

• 1) Hosoya K, Kubo H, Natsume H, Sugibayashi K, Morimoto Y. Evaluation of enhancers to increase nasal absorption using Ussing chamber technique. Biol. Pharm. Bull., 17, 316-322 (1994).
• 2) Hosoya K, Kubo H, Natsume H, Sugibayashi K, Morimoto Y, Yamashita S. The structural barrier of absorptive mucosae: site difference of the permeability of fluorescein isothiocyanate-labelled dextran in rabbits. Biopharm. Drug Dispos., 14, 685-695 (1993).
• 3) McMartin C, Hutchinson LE, Hyde R, Peters GE. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pharm. Sci., 76, 535-540 (1987).
• 4) Natsume H, Iwata S, Ohtake K, Miyamoto M, Yamaguchi M, Hosoya K, Kobayashi D, Sugibayashi K, Morimoto Y. Screening of cationic compounds as an absorption enhancer for nasal drug delivery. Int. J. Pharm., 185, 1-12 (1999).
• 5) Ohtake K, Maeno T, Ueda H, Natsume H, Morimoto Y. Poly-L-arginine predominantly increases the paracellular permeability of hydrophilic macromolecules across rabbit nasal epithelium in vitro. Pharm. Res., 20, 153-160 (2003).

Terms in the title (5)： 吸収促進剤 ,  L-オルニチン ,  複合体 ,  調製 ,  評価