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J-GLOBAL ID：201702276278048933   Reference number：17A1533342

Characterization of poly(L-glutamic acid)-grafted hyaluronan as a novel candidate medicine and biomedical device for intra-articular injection

関節内注射に対する新しい候補医薬品と生物医学デバイスとしてのポリ(L-グルタミン酸移植ヒアルロナンの特徴

Author (6)： Muramatsu Kazuaki (Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan) ,  Tajima Yuya (Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan) ,  Kaneko Rin (Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan) ,  Yanagita Yuta (Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan) ,  Hirai Hiroyuki (Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan) ,  Hiura Nana (Division of Life Science and Engineering, School of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama-cho, Hiki-gun, Saitama, 350-0394, Japan)
Material： Journal of Biomedical Materials Research. Part A  (J Biomed Mater Res Pt A)
Volume： 105  Issue： 11  Page： 3006-3016  Publication year： Nov. 2017 
JST Material Number： E0528B  ISSN： 1549-3296  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： local administration ,...
Semi thesaurus term： intra-articular administration ,...

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Author keywords (4)： hyaluronan ,  poly(L-glutamic acid) ,  cartilage ,  intra-articular injection

JST classification (2)： Medical materials  (GA05040H) ,  Basic medicine on musculoskeletal system  (GG01020B)

Substance index (2)： Glutamic acid ,  Iodoacetic acid

Reference (68)：

• Weissman B, Meyer K. The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J Am Chem Soc 1954;76: 1753-1757.
• Kawasaki K, Ochi M, Uchio Y, Adachi N, Matsusaki M. Hyaluronic acid enhances proliferation and chondroitin sulfate synthesis in cultured chondrocytes embedded in collagen gels. J Cell Physiol 1999;179:142-148.
• Andhare RA, Takahashi N, Knudson W, Knudson CB. Hyaluronan promotes the chondrocyte response to BMP-7. Osteoarthritis Cartilage 2009;17:906-916.
• Yatabe T, Mochizuki S, Takizawa M, Chijiiwa M, Okada A, Kimura T, Fujita Y, Matsumoto H, Toyama Y, Okada Y. Hyaluronan inhibits expression of ADAMTS4 (Aggrecanase-1) in human osteoarthritic chondrocytes. Ann Rheum Dis 2009;68:1051-1058.
• Hashizume M, Mihara M. High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Biochem Biophys Res Commun 2010;403:184-189.

Terms in the title (6)： 関節内注射 ,  医薬品 ,  生物医学 ,  L-グルタミン酸 ,  移植 ,  ヒアルロナン