Art

J-GLOBAL ID：201702277788131840   Reference number：17A0504344

Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer’s disease

アルツハイマー病の精神神経症状に対するYokukansan(抑肝散)の無作為化二重盲検プラセボ対照多施設共同試験

Author (34)： Furukawa Katsutoshi (Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku University, Sendai, Japan) ,  Tomita Naoki (Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku University, Sendai, Japan) ,  Uematsu Daisuke (Uematsu Neurological Clinic, Saitama, Japan) ,  Okahara Kazunori (Keimei Memorial Hospital, Kunitomi, Japan) ,  Shimada Hiroyuki (Department of Geriatrics and Neurology, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Ikeda Masaki (Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Matsui Toshifumi (National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Japan) ,  Kozaki Koichi (Department of Geriatric Medicine, Kyorin University School of Medicine, Mitaka, Japan) ,  Fujii Masahiko (Yamagata Kousei Hospital, Yamagata, Japan) ,  Ogawa Tatsuji (Aoba Neurosurgical Clinic, Sendai, Japan) ,  Umegaki Hiroyuki (Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Urakami Katsuya (Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Japan) ,  Nomura Hiroshi (Hiroshi Nomura Neurology Clinic, Sendai, Japan) ,  Kobayashi Naoto (Azuma Street Clinic, Fukushima, Japan) ,  Nakanishi Aki (Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Suita, Japan) ,  Washimi Yukihiro (Department of Cognitive Disorders, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Yonezawa Hisashi (Department of Neurology, Iwate Medical University, Morioka, Japan) ,  Takahashi Satoshi (Department of Neurology, Iwate Medical University, Morioka, Japan) ,  Kubota Masaharu (Kusakabe Memorial Hospital, Yamanashi, Japan) ,  Wakutani Yosuke (Neurology, Kurashiki Heisei Hospital, Kurashiki, Japan) ,  Ito Daisuke (Department of Neurology, School of Medicine, Keio University, Tokyo, Japan) ,  Sasaki Takahiro (Department of Neurology, School of Medicine, Saitama Medical University, Moroyama, Japan) ,  Matsubara Etsuro (Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Yufu, Japan) ,  Une Kaori (Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku University, Sendai, Japan) ,  Ishiki Aiko (Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku University, Sendai, Japan) ,  Yahagi Yukie (Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan) ,  Shoji Mikio (Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Yufu, Japan) ,  Sato Hiroyasu (Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan) ,  Terayama Yasuo (Department of Neurology, Iwate Medical University, Morioka, Japan) ,  Kuzuya Masafumi (Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Araki Nobuo (Department of Neurology, School of Medicine, Saitama Medical University, Moroyama, Japan) ,  Kodama Manabu (Kodama Hospital, Ishinomaki, Japan) ,  Yamaguchi Takuhiro (Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan) ,  Arai Hiroyuki (Department of Geriatrics and Gerontology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku University, Sendai, Japan)
Material： Geriatrics & Gerontology International  (Geriatrics and Gerontology International)
Volume： 17  Issue： 2  Page： 211-218  Publication year： Feb. 2017 
JST Material Number： W1574A  ISSN： 1444-1586  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： mini-mental state examination ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0504344&from=J-GLOBAL&jstjournalNo=W1574A") }}

Author keywords (5)： Alzheimer’s disease ,  behavioral and psychological symptoms of dementia ,  Kampo medicine ,  Neuropsychiatric Inventory Brief Questionnaire Form ,  Yokukansan

JST classification (2)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y) ,  Clinical application of crude drugs  (GX06030U)

Reference (26)：

• Finkel SI, Costa e Silva J, Cohen G, Miller S, Sartorius N. Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 1996; 8 (Suppl 3): 497-500.
• Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the cache county study on memory in aging. Am J Psychiatry 2000; 157: 708-714.
• Ferri CP, Ames D, Prince M. Behavioral and psychological symptoms of dementia in developing countries. Int Psychogeriatr 2004; 16: 441-459.
• Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. Am J Psychiatry 1990; 147: 1049-1051.
• Coen RF, Swanwick GR, O'Boyle CA, Coakley D. Behaviour disturbance and other predictors of carer burden in Alzheimer's disease. Int J Geriatr Psychiatry 1997; 12: 331-336.

Terms in the title (7)： アルツハイマー ,  精神神経症状 ,  抑肝散 ,  二重盲検 ,  プラセボ ,  対照 ,  多施設共同試験