Art

J-GLOBAL ID：201702278707443164   Reference number：17A0681249

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

ヒト癌に関係する最初に同定された細菌蛋白質Helicobacter pylori(ピロリ菌)CagAの構造および機能

Author (1)： HATAKEYAMA Masanori (Department of Microbiology, Graduate School of Medicine, The University of Tokyo)
Material： Proceedings of the Japan Academy. Series B. Physical and Biological Sciences  (日本学士院紀要 B)
Volume： 93  Issue： 4  Page： 196-219(J-STAGE)  Publication year： 2017 
JST Material Number： G0485B  ISSN： 0386-2208  CODEN： PJABDW  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Cancer ,...

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Author keywords (6)： gastric cancer ,  Helicobacter pylori ,  CagA ,  EPIYA motif ,  CM motif ,  Hit-and-Run carcinogenesis

JST classification (3)： Carcinogenic mechanisms and factors  (GE02020C) ,  Stomach  (EJ06030C) ,  Physiology and pathogenicity of microbial infection  (EG03053T)

Reference (174)：

• 1) Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D.M., Forman, D. and Bray, F. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136, E359-E386.
• 2) Lauren, P. (1965) The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand. 64, 31-49.
• 3) Qiu, M.Z., Cai, M.Y., Zhang, D.S., Wang, Z.Q., Wang, D.S., Li, Y.H. and Xu, R.H. (2013) Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China. J. Transl. Med. 11, 58.
• 4) Correa, P. (1992) Human gastric carcinogenesis: a multistep and multifactorial process - first American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res. 52, 6735-6740.
• 5) Takemura, S., Yashiro, M., Sunami, T., Tendo, M. and Hirakawa, K. (2004) Novel models for human scirrhous gastric carcinoma in vivo. Cancer Sci. 95, 893-900.

Terms in the title (7)： ヒト ,  癌 ,  同定 ,  細菌蛋白質 ,  Helicobacter ,  ピロリ菌 ,  CagA