Art

J-GLOBAL ID：201702279186764296   Reference number：17A1431754

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

コアフコシル化の遮断T細胞のPD-1を促進する抗腫瘍免疫応答の細胞表面発現を減少させる【Powered by NICT】

Author (8)： Okada Masahiro (Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Chikuma Shunsuke (Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Kondo Taisuke (Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Hibino Sana (Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan) ,  Machiyama Hiroaki (Department of Immunology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan) ,  Yokosuka Tadashi (Department of Immunology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan) ,  Nakano Miyako (Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-hiroshima, Hiroshima 739-8530, Japan) ,  Yoshimura Akihiko (Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan)
Material： Cell Reports
Volume： 20  Issue： 5  Page： 1017-1028  Publication year： 2017 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Programmed cell death 1 (PD-1)...

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Thesaurus term： *tumor ,  antibody ,  dysfunction ,  *tumor immunity ,  pharmacology ,  *T cell ,  gene ,  patient ,  screening(inspection) ,  interaction
Semi thesaurus term： 調節因子 ,  リガンド ,  T細胞活性化 ,  *細胞表面 ,  *フコシル化 , 【Automatic Indexing@JST】

Author keywords (4)： PD-1 ,  core fucosylation ,  CRISPR screen ,  tumor immunotherapy

JST classification (5)： Tumor immunity  (ED03040A) ,  Immunological reaction in general  (ED03010T) ,  Clinical application of immunotherapeutic agents and blood preparations  (GW22020O) ,  Surgical treatment for tumors  (GE03033T) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (10)： コア ,  フコシル化 ,  遮断 ,  T細胞 ,  PD-1 ,  促進 ,  抗腫瘍免疫 ,  応答 ,  細胞表面 ,  発現