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J-GLOBAL ID：201702280501765845   Reference number：17A1969497

Improvement in the water solubility of drugs with a solid dispersion system by spray drying and hot-melt extrusion with using the amphiphilic polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer and d-mannitol

両親媒性ポリビニルカプロラクタムポリビニル酢酸ポリエチレングリコールグラフト共重合体とD-マンニトールを用いた噴霧乾燥法とホットメルト押出による固体分散系を有する薬物の水溶解度の改善【Powered by NICT】

Author (9)： Ogawa Noriko (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Hiramatsu Tomoki (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Suzuki Ryohei (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Okamoto Ryohei (Department of Mechanical Engineering, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa Cho, Toyota City, Aichi 470-0392, Japan) ,  Shibagaki Kohei (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Fujita Kosuke (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Takahashi Chisato (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Kawashima Yoshiaki (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan) ,  Yamamoto Hiromitsu (Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan)
Material： European Journal of Pharmaceutical Sciences  (Eur J Pharm Sci)
Volume： 111  Page： 205-214  Publication year： 2018 
JST Material Number： W0673A  ISSN： 0928-0987  CODEN： EPSCED  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The aim of this study was to p...

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Thesaurus term： *spray drying ,  amorphous state ,  filler(pharmaceuticals) ,  thermal analysis ,  *amphiphilic ,  water solubility ,  *solubility(ratio) ,  characterization ,  *dissolution ,  dispersed particle ,  drug release
Semi thesaurus term： FTIRスペクトル ,  物理化学的性質 ,  *水溶解度 ,  *固体分散体 , 【Automatic Indexing@JST】

Author keywords (5)： Solid dispersion ,  Spray drying ,  Hot-melt extrusion technique ,  Amorphous ,  Powder technology

JST classification (2)： Physicochemical characteristics of drugs  (GV01060M) ,  Physical pharmacy  (GY01012A)

Terms in the title (11)： 両親媒性 ,  酢酸 ,  ポリエチレングリコール ,  グラフト共重合体 ,  D-マンニトール ,  噴霧乾燥 ,  メルト ,  押出 ,  固体分散系 ,  薬物 ,  水溶解度