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J-GLOBAL ID：201702280649401575   Reference number：17A1708728

Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment

脳におけるロイシンリッチα2-糖蛋白質の過剰発現は記憶障害に寄与する【Powered by NICT】

Author (16)： Akiba Chihiro (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Nakajima Madoka (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Miyajima Masakazu (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Ogino Ikuko (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Miura Masami (Neurophysiology Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Inoue Ritsuko (Neurophysiology Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Nakamura Eri (Laboratory of Disease Model Research, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Kanai Fumio (Laboratory of Disease Model Research, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Tada Norihiro (Laboratory of Disease Model Research, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Kunichika Miyuki (Laboratory of Morpheme Analysis Imaging Research, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Yoshida Mitsutaka (Laboratory of Morpheme Analysis Imaging Research, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Nishimura Kinya (Neurophysiology Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan) ,  Nishimura Kinya (Department of Anesthesiology, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Kondo Akihide (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Sugano Hidenori (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan) ,  Arai Hajime (Department of Neurosurgery, Juntendo University Graduate School of Medicine, Tokyo, Japan)
Material： Neurobiology of Aging  (Neurobiol Aging)
Volume： 60  Page： 11-19  Publication year： 2017 
JST Material Number： W0356A  ISSN： 0197-4580  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： We previously reported increas...

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Thesaurus term： transgenic mouse ,  synaptic vesicle ,  *memory disorder ,  synapse ,  Long-Term Potentiation ,  immunostaining ,  excitatory postsynaptic potential ,  Eumetopias jubata ,  *glycoprotein ,  Western blotting ,  human ,  Hippocampal neuron ,  Cognition Disorders ,  *overexpression ,  membrane and film ,  biomembrane ,  Endomembrane system ,  electrophysiology ,  bioassay ,  aliphatic amine ,  aliphatic carboxylic acid ,  branched-chain amino acid

Author keywords (7)： Leucine-rich α2-glycoprotein ,  Memory ,  Aging ,  Hippocampus ,  Synaptic plasticity ,  Field excitatory postsynaptic potentials ,  Long-term potentiation

JST classification (2)： Central nervous system  (EJ12030F) ,  Basic neurology  (GN01020W)

Substance index (1)： Leucine

Terms in the title (4)： 脳 ,  糖蛋白質 ,  過剰発現 ,  記憶障害