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J-GLOBAL ID：201702280875451843   Reference number：17A1047385

5-Bromoindirubin 3′-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase

5Bromoindirubin 3′-(O-オキシラン-2-イルメチル)オキシム:長時間作用型抗腫瘍薬とエポキシドヒドロラーゼの自殺阻害剤【Powered by NICT】

Author (6)： Ichimaru Yoshimi (School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Fujii Takeshi (School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Saito Hiroaki (School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Sano Makoto (Division of Pathology, Department of Pathology and Microbiology, School of Medicine, Nihon University, 30-1 Ohyaguchi-Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan) ,  Uchiyama Taketo (School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan) ,  Miyairi Shinichi (School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 25  Issue： 17  Page： 4665-4676  Publication year： Sep. 01, 2017 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Indirubin 3′-oxime (Indox (1b)...

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Thesaurus term： *oxime ,  chemical synthesis ,  *structure-activity relationship ,  *antitumor drug ,  epoxide hydratase ,  enzyme inhibitor ,  HepG2 cell ,  substitution reaction ,  cytotoxicity ,  docking ,  molecular recognition ,  metabolism ,  enzyme kinetics
Semi thesaurus term： epoxide hydrolase ,  自殺阻害剤 ,  長期作用抗癌剤 ,  molecular docking ,  aromatic substitution

Author keywords (5)： 5-Bromoindirubin 3′-(O-oxiran-2-ylmethyl)oxime ,  Long-acting anticancer agent ,  Structure-activity relationships ,  Epoxide hydrolase ,  Suicide inhibition

JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Structure-activity relationship of drugs  (GV01050B) ,  Enzyme in general  (EB09010D)

Substance index (1)： 5′-Bromo-3-(glycidyloxyimino)-Δ^2,3′-bi[indoline]-2′-one

Terms in the title (6)： オキシラン ,  オキシム ,  抗腫瘍薬 ,  エポキシドヒドロラーゼ ,  自殺 ,  阻害剤