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J-GLOBAL ID：201702281029977779   Reference number：17A1906176

Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis

ヒト多能性幹細胞由来の心筋細胞を用いた薬物の催不整脈作用と遺伝子発現解析の評価系

Author (8)： Higa Arisa (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Hoshi Hirotaka (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Yanagisawa Yuka (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Ito Emi (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Morisawa Gaku (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Imai Jun-ichi (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Watanabe Shinya (Medical-Industrial Translational Research Center, Fukushima Medical University) ,  Takagi Motoki (Medical-Industrial Translational Research Center, Fukushima Medical University)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 42  Issue： 6  Page： 755-761(J-STAGE)  Publication year： 2017 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *induced pluripotent stem cell ,...
Semi thesaurus term： *arrhythmogenic effect ,...

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Author keywords (5)： Arrhythmia ,  Arrhythmogenesis ,  QT prolongation ,  Human-induced pluripotent stem cell-derived cardiomyocytes ,  Gene expression analysis

JST classification (1)： Research methods  (GV01020U)

Reference (22)：

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• Dick, E., Rajamohan, D., Ronksley, J. and Denning, C. (2010): Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening. Biochem. Soc. Trans., 38, 1037-1045.
• Fermini, B. and Fossa, A.A. (2003): The impact of drug-induced QT interval prolongation on drug discovery and development. Nat. Rev. Drug Discov., 2, 439-447.

Terms in the title (7)： ヒト ,  多能性幹細胞 ,  心筋細胞 ,  薬物 ,  催不整脈作用 ,  遺伝子発現解析 ,  評価