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J-GLOBAL ID：201702281144146261   Reference number：17A0870028

Antitumor activity of selenium compounds and its underlying mechanism in human oral squamous cell carcinoma cells: A preliminary study

ヒト口腔扁平上皮癌細胞におけるセレン化合物の抗腫瘍活性およびその基になる機構:初期的な研究

Author (9)： Endo Manabu (Department of Oral Surgery, Fukushima Medical University Hospital, 1 Hikarigaoka, Fukushima 960-1295, Japan) ,  Endo Manabu (Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan) ,  Hasegawa Hiroshi (Department of Oral Surgery, Fukushima Medical University Hospital, 1 Hikarigaoka, Fukushima 960-1295, Japan) ,  Kaneko Tetsuharu (Department of Oral Surgery, Fukushima Medical University Hospital, 1 Hikarigaoka, Fukushima 960-1295, Japan) ,  Kanno Chihiro (Department of Oral Surgery, Fukushima Medical University Hospital, 1 Hikarigaoka, Fukushima 960-1295, Japan) ,  Monma Tsutomu (Department of Oral Surgery, Ohara General Hospital, 6-11 Omachi, Fukushima 960-8611, Japan) ,  Kano Makoto (Department of Otorhinolaryngology, Head and Neck Surgery, Ohara General Hospital, 6-11 Omachi, Fukushima 960-8611, Japan) ,  Shinohara Fumiaki (Department of Oral Microbiology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan) ,  Takahashi Tetsu (Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan)
Material： Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (Web)  (J Oral Maxillofac Surg Med Pathol (Web))
Volume： 29  Issue： 1  Page： 17-23  Publication year： 2017 
JST Material Number： U0704A  ISSN： 2212-5558  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,...
Semi thesaurus term： oral squamous cell carcinoma cell ,...

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Author keywords (4)： Selenium compounds ,  Apoptosis ,  Endoplasmic reticulum stress ,  Akt pathway

JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Tumors(=neoplasms)of tooth and mouth(=oral cavity)  (GT04000N) ,  Aliphatic selenium and tellurium compounds  (CF03170U)

Substance index (2)： Selenomethionine ,  Se-Methylselenocysteine

Reference (22)：

• Dong Y, Lisk D, Block E. Characterization of the biological activity of gammaglutamyl-Se-methylselenocysteine: a novel, naturally occurring anticancer agent from garlic. Cancer Res 2001;61:2923-8.
• Kiremidjian-Schumacher L, Roy M. Effect of selenium on the immunocompetence of patients with head and neck cancer and on adoptive immunotherapy of early and established lesions. Biofactors 2001;14:161-8.
• Sinha R, El-Bayoumy K. Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds. Curr Cancer Drug Targets 2004;4:13-28.
• Nakashio A, Fujita N, Rokudai S, Sato S, Tsuruo T. Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis. Cancer Res 2000;60:5303-9.
• Rokudai S, Fujita N, Kitahara O, Nakamura Y, Tsuruo T. Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Mol Cell Biol 2002;22:8695-708.

Terms in the title (6)： ヒト ,  口腔扁平上皮癌細胞 ,  セレン化合物 ,  抗腫瘍活性 ,  初期 ,  研究