Art

J-GLOBAL ID：201702282960092863   Reference number：17A0304272

Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps

鼻ポリープを伴う慢性鼻副鼻腔炎におけるブドウ球菌エンテロトキシン誘導IL-5とIL-13とIL-17AとIFN-γ産生に対するTLR3シグナル伝達の制御性効果

Author (13)： Okano Mitsuhiro (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Fujiwara Tazuko (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Kariya Shin (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Higaki Takaya (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Makihara Sei-ichiro (Department of Otorhinolaryngology, Kagawa Rosai Hospital) ,  Haruna Takenori (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Noyama Yasuyuki (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Koyama Takahisa (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Omichi Ryotaro (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Orita Yorihisa (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Miki Kentaro (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) ,  Kanai Kengo (Department of Otorhinolaryngology, Kagawa Prefectural Central Hospital) ,  Nishizaki Kazunori (Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
Material： Allergology International  (Allergol Int)
Volume： 65  Issue： 1  Page： 96-102(J-STAGE)  Publication year： Jan. 2016 
JST Material Number： L6446A  ISSN： 1323-8930  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： IL13 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0304272&from=J-GLOBAL&jstjournalNo=L6446A") }}

Author keywords (1)： Chronic rhinosinusitis with nasal polyps; IL-5; IL-10; Poly(IC); Toll-like receptor

JST classification (3)： Cytokines  (EB08090G) ,  Diseases of ear,nose,pharynx and larynx  (GQ03000X) ,  Cell physiology in general  (EF02010S)

Substance index (2)： Dinoprostone ,  Diclofenac

Reference (39)：

• 1. Takeno S, Hirakawa K, Ishino T. Pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis in the Japanese population. Allergol Int 2010;59:247-56.
• 2. van Drunen CM, Mjosberg JM, Segboer CL, Cornet ME, Fokkens WJ. Role of innate immunity in the pathogenesis of chronic rhinosinusitis: progress and new avenues. Curr Allergy Asthma Rep 2012;12:120-6.
• 3. Okano M, Kariya S, Ohta N, Imoto Y, Fujieda S, Nishizaki K. Association and management of eosinophilic inflammation in upper and lower airways. Allergol Int 2015;64:131-8.
• 4. Nonaka M, Ogihara N, Fukumoto A, Sakanushi A, Kusama K, Pawankar R, et al. Nasal polyp fibroblasts produce MIP-3alpha in response to toll-like receptor ligands and cytokine stimulation. Rhinology 2010;48:41-6.
• 5. Suzaki H, Watanebe S, Pawankar R. Rhinosinusitis and asthma-microbiome and new perspectives. Curr Opin Allergy Clin Immunol 2013;13:45-9.

Terms in the title (11)： 鼻ポリープ ,  慢性鼻副鼻腔炎 ,  ブドウ球菌エンテロトキシン ,  誘導 ,  IL-5 ,  IL-13 ,  IL-17A ,  IFN-γ ,  TLR3 ,  シグナル伝達 ,  制御性