Art

J-GLOBAL ID：201702283003284331   Reference number：17A0681582

Efficacy and Safety of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia

ホモ接合家族性高コレステロール血症の日本人患者におけるロミタピドの有効性と安全性

Author (8)： Harada-Shiba Mariko (National Cerebral and Cardiovascular Research Center) ,  Ikewaki Katsunori (National Defense Medical College) ,  Nohara Atsushi (Kanazawa University Graduate School of Medical Sciences) ,  Otsubo Yoshihiko (Shin-Koga Clinic, Medical Group Tenjin-kai) ,  Yanagi Koji (Kenporen Osaka Central Hospital) ,  Yoshida Masayuki (Tokyo Medical and Dental University) ,  Chang Qing (Aegerion Pharmaceuticals, Inc.) ,  Foulds Pamela (Aegerion Pharmaceuticals, Inc.)
Material： Journal of Atherosclerosis and Thrombosis (Web)  (J Atheroscler Thromb (Web))
Volume： 24  Issue： 4  Page： 402-411(J-STAGE)  Publication year： 2017 
JST Material Number： U0153A  ISSN： 1880-3873  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *Homozygous familial hypercholesterolemia ,...

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Author keywords (4)： Homozygous familial hypercholesterolemia ,  Lomitapide ,  Hypercholesterolemia ,  LDL-C

JST classification (1)： Treatment for metabolic diseases,nutritional diseases.  (GD05030F)

Substance index (1)： BMS-201038

Reference (29)：

• 1) Cuchel M, Bruckert E, Ginsberg HN, Raal FJ, Santos RD, Hegele RA, Kuivenhoven JA, Nordestgaard BG, Descamps OS, Steinhagen-Thiessen E, Tybjaerg-Hansen A, Watts GF, Averna M, Boileau C, Boren J, Catapano AL, Defesche JC, Hovingh GK, Humphries SE, Kovanen PT, Masana L, Pajukanta P, Parhofer KG, Ray KK, Stalenhoef AF, Stroes E, Taskinen MR, Wiegman A, Wiklund O, Chapman MJ: Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J, 2014; 35: 2146-2157
• 2) Beigel R, Beigel Y: Homozygous familial hypercholesterolemia: long term clinical course and plasma exchange therapy for two individual patients and review of the literature. J Clin Apher, 2009; 24: 219-224
• 3) Hobbs HH, Brown MS, Goldstein JL: Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat, 1992; 1: 445-466
• 4) Kolansky DM, Cuchel M, Clark BJ, Paridon S, McCrindle BW, Wiegers SE, Araujo L, Vohra Y, Defesche JC, Wilson JM, Rader DJ: Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia. Am J Cardiol, 2008; 102: 1438-1443
• 5) Gidding SS, Ann Champagne M, de Ferranti SD, Defesche J, Ito MK, Knowles JW, McCrindle B, Raal F, Rader D, Santos RD, Lopes-Virella M, Watts GF, Wierzbicki AS, and on behalf of the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, and Council on Lifestyle and Cardiometabolic Health: The agenda for familial hypercholesterolemia: a scientific statement from the American Heart Association. Circulation, 2015; 132: 2167-2192

Terms in the title (7)： ホモ接合 ,  家族性高コレステロール血症 ,  日本人 ,  患者 ,  ロミタピド ,  有効性 ,  安全性