Art

J-GLOBAL ID：201702283518055382   Reference number：17A1537999

Towards an understanding of the isotype-specific functions of tubulin in neurons: Technical advances in tubulin expression and purification

ニューロンにおけるチューブリンのアイソタイプ特異的機能の理解に向けて:チューブリンの発現と精製の技術的進歩

Author (2)： Minoura Itsushi (Laboratory for Molecular Biophysics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan) ,  Minoura Itsushi (Goryo Chemical Inc., Earee Bldg. 5F, Kita 8 Nishi 18-35-100, Chuo-ku, Sapporo 060-0008, Japan)
Material： Neuroscience Research  (神経科学)
Volume： 122  Page： 1-8  Publication year： Sep. 2017 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 文献レビュー  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Tubulin ,...
Semi thesaurus term： tubulinopathy ,...

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Author keywords (6)： Brain malformation ,  CFEOM3 ,  TUBB3 ,  Recombinant tubulin expression ,  Saccharomyces cerevisiae ,  Schizosaccharomyces pombe

JST classification (4)： Central nervous system  (EJ12030F) ,  Physiology of development(=generation)in general  (EJ16010L) ,  Proteins and peptides in general  (EB03010N) ,  Basic neurology  (GN01020W)

Reference (78)：

• Amrom, D., Tanyalcin, I., Verhelst, H., Deconinck, N., Brouhard, GJ., Decarie, J.C., Vanderhasselt, T., Das, S., Hamdan, F.F., Lissens, W., Michaud, J.L, Jansen, A.C., 2014. Polymicrogyria with dysmorphic basal ganglia? Think tubulin ! Clin. Genet. 85, 178-183.
• Ayaz, P., Ye, X., Huddleston, P., Brautigam, CA., Rice, LM., 2012. A TOG:alphabeta-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase. Science 337, 857-860.
• Ayaz, P., Munyoki, S., Geyer, E.A., Piedra, F.A., Vu, E.S., Bromberg, R., Otwinowski, Z., Grishin, N.V., Brautigam, CA., Rice, LM., 2014. A tethered delivery mechanism explains the catalytic action of a microtubule polymerase. eLife 3, e03069.
• Bamba, Y., Shofuda, T., Kato, M., Pooh, R.K., Tateishi, Y., Takanashi, J., Utsunomiya, H., Sumida, M., Kanematsu, D., Suemizu, H., Higuchi, Y., Akamatsu, W., Gallagher, D., Miller, F.D., Yamasaki, M., Kanemura, Y., Okano, H., 2016. In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. Mol. Brain 9, 70.
• Bode, CJ., Gupta, M.L, Suprenant, K.A., Himes, R.H., 2003. The two alpha-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro. EMBO Rep. 4, 94-99.

Terms in the title (5)： ニューロン ,  チューブリン ,  理解 ,  発現 ,  精製