Art

J-GLOBAL ID：201702283580842208   Reference number：17A0496254

Syntheses and mucosal adjuvant activity of simplified oleanolic acid saponins possessing cinnamoyl ester

シンナモイルエステルを有する単純化オレアノール酸サポニンの合成と粘膜アジュバント活性

Author (12)： Shirahata Tatsuya (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Nagai Takayuki (Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Hirata Nozomu (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Yokoyama Masaki (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Katsumi Tatsuya (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Konishi Naruki (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Nishino Takashi (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Makino Kazuishi (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Yamada Haruki (Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Kaji Eisuke (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Kiyohara Hiroaki (Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan) ,  Kobayashi Yoshinori (School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 25  Issue： 6  Page： 1747-1755  Publication year： Mar. 15, 2017 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *adjuvant ,  *influenza vaccine ,  antibody titer ,  *saponin ,  Structure-Activity Relationship ,  *acyl group ,  Glycosylation ,  Mus musculus ,  ELISA ,  immunoglobulin A ,  immunoglobulin G ,  immunoglobulin E ,  ester ,  *Adjuvants, Vaccine ,  intra-nasal influenza vaccine ,  *Mucosal Adjuvant ,  Myomorpha ,  bioassay
Semi thesaurus term： *オレアナン型サポニン ,  *シンナモイル基

Author keywords (4)： Mucosal adjuvant ,  Vaccine ,  Glycosylation ,  Saponin

JST classification (5)： Glycosides  (CF10057O) ,  Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Basic research of antiviral drugs  (GW17040O) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： 3β-Hydroxyoleana-12-ene-28-oic acid 4-O-[3-(3,4-dimethoxyphenyl)propenoyl]-β-D-glucopyranosyl ester

Terms in the title (5)： 単純化 ,  オレアノール酸 ,  サポニン ,  粘膜アジュバント ,  活性