Art

J-GLOBAL ID：201702285681048624   Reference number：17A0211194

A Concise One-Pot Organo- and Biocatalyzed Preparation of Enantiopure Hexahydrofuro[2,3-b]furan-3-ol: An Approach to the Synthesis of HIV Protease Inhibitors

エナンチオ純粋なヘキサヒドロフルオロ[2,3-b]フラン-3-オールの簡易なワンポット有機および生体触媒調製 HIVプロテアーゼ阻害剤合成への方法

Author (9)： Kanemitsu Takuya (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Inoue Mizuho (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Yoshimura Nono (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Yoneyama Kazutoshi (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Watarai Rie (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Miyazaki Michiko (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Odanaka Yuki (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Nagata Kazuhiro (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html) ,  Itoh Takashi (School of Pharmacy, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, http://www10.showa-u.ac.jp/obchem/index.html)
Material： European Journal of Organic Chemistry  (Eur J Org Chem)
Volume： 2016  Issue： 10  Page： 1874-1880  Publication year： 2016 
JST Material Number： W1026A  ISSN： 1434-193X  CODEN： EJOCFK  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *optical resolution ,  enzyme inhibitor ,  *proteinase inhibitor ,  one-pot synthesis ,  condensation reaction ,  lipase
Semi thesaurus term： *HIV-1 protease inhibitors ,  thiourea derivatives ,  *enzyme catalyst ,  kinetic resolution ,  organocatalyst

Author keywords (5)： Organocatalysis ,  Enzyme catalysis ,  Thioureas ,  Kinetic resolution ,  Inhibitors

JST classification (3)： Catalytic reactions in general  (CB06080F) ,  Enzyme in general  (EB09010D) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (9)： 2,3-Dihydrofuran ,  Darunavir ,  1,4-Dioxane-2,5-diol ,  Schreiner’s thiourea ,  (3aβ,6aβ)-Hexahydrofuro[2,3-b]furan-3α-ol ,  Acetic acid (3S)-2,3,3aα,4,5,6aα-hexahydrofuro[2,3-b]furan-3β-yl ester ,  N-(2-Methylpropyl)-N-[(2R,3S)-2-hydroxy-3-amino-4-phenylbutyl]-4-nitrobenzenesulfonamide ,  Carbonic acid (3R,3aβ,6aβ)-hexahydrofuro[2,3-b]furan-3α-yl 2,5-dioxopyrrolizino ,  [(2S,3R)-3-Hydroxy-4-[isopropyl(4-nitrophenylsulfonyl)amino]-1-phenylbutane-2-yl]carbamic acid (3R)-2,3,3aβ,4,5,6aβ-hexahydrofuro[2,3-b]furan-3α-yl ester

Terms in the title (5)： フラン ,  ポット ,  生体触媒 ,  調製 ,  HIVプロテアーゼ阻害剤