Art

J-GLOBAL ID：201702286558579864   Reference number：17A0040946

A swine model of acute thrombocytopenia with prolonged bleeding time produced by busulfan

ブスルファンにより生じる出血時間延長を伴う急性血小板減少症のブタモデル

Author (9)： Abe Tomoyuki (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Abe Tomoyuki (Division of Stem Cell Research and Drug Development, Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan) ,  Kono Shota (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Kono Shota (Division of Stem Cell Research and Drug Development, Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan) ,  Ohnuki Takahiro (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hishikawa Shuji (Division for Medical Skill Training, Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan) ,  Kunita Satoshi (Division of Development of Animal Resource, Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan) ,  Hanazono Yutaka (Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan) ,  Hanazono Yutaka (Division of Stem Cell Research and Drug Development, Center for Development of Advanced Medical Technology, Jichi Medical University, Tochigi, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 65  Issue： 4  Page： 345-351(J-STAGE)  Publication year： 2016 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Sus scrofa domesticus ,...
Semi thesaurus term： Bone marrow depression

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Author keywords (5)： large animal model ,  busulfan ,  pig ,  prolonged bleeding time ,  thrombocytopenia

JST classification (1)： Basic hematology  (GK01020N)

Substance index (1)： Busulfan

Reference (26)：

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• 3. Bassols A., Costa C., Eckersall P.D., Osada J., Sabrià J., and Tibau J. 2014. The pig as an animal model for human pathologies: A proteomics perspective. Proteomics Clin. Appl. 8: 715-731.
• 4. Blajchman M.A. 1999. Substitutes for success. Nat. Med. 5: 17-18.
• 5. Blajchman M.A. and Lee D.H. 1997. The thrombocytopenic rabbit bleeding time model to evaluate the in vivo hemostatic efficacy of platelets and platelet substitutes. Transfus. Med. Rev. 11: 95-105.

Terms in the title (5)： ブスルファン ,  出血 ,  血小板減少症 ,  ブタ ,  モデル