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J-GLOBAL ID：201702286693088871   Reference number：17A1047279

Enantioselective synthesis of methyl 2-[1-[(tert-butoxycarbonyl)amino]ethyl]-4-methyloxazole-5-carboxylate by a one-pot enamide cyclization

ワンポットエナミド環化によるメチル2-[1-[(tert-ブトキシカルボニル)アミノ]エチル]-4-メチルオキサゾール-5-カルボキシラートのエナンチオ選択的合成【Powered by NICT】

Author (7)： Magata Takuji (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan) ,  Nagano Saeka (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan) ,  Endo Takuya (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan) ,  Kawaida Jun (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan) ,  Nagaoka Shiho (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan) ,  Hirokawa Yoshimi (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan) ,  Maezaki Naoyoshi (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tondabayashi, Osaka 584-8540, Japan)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 58  Issue： 37  Page： 3628-3630  Publication year： Sep. 13, 2017 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Methyl 2-[1-[(tert-butoxycarbo...

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Thesaurus term： one-pot synthesis ,  asymmetric synthesis ,  enamine ,  carboxamide ,  *cyclization reaction ,  oxygen heterocyclic compound ,  nitrogen heterocyclic compound ,  bromination
Semi thesaurus term： enamide ,  *Oxazoles

Author keywords (5)： Unusual amino acid ,  Oxazole synthesis ,  Cyclization ,  β-Acylamino-α-bromoenoate ,  18-Diazabicyclo[5.4.0]undec-7-ene

JST classification (1)： Oxazoles,isoxazoles  (CF07080Y)

Substance index (4)： 2-[(R)-1-(tert-Butoxycarbonylamino)ethyl]-4-methyloxazole-5-carboxylic acid methyl ester ,  2-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]-4-methyloxazole-5-carboxylic acid tert-butyl ester ,  2-[(R)-1-[(tert-Butyloxycarbonyl)amino]-2-methylpropyl]-4-methyloxazole-5-carboxylic acid methyl ester ,  2-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]-4-ethyloxazole-5-carboxylic acid methyl ester

Terms in the title (5)： 環化 ,  TERT ,  ブトキシカルボニル ,  カルボキシラート ,  エナンチオ選択的合成