Art

J-GLOBAL ID：201702286883068890   Reference number：17A1137982

Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas

非末梢肺細胞型肺腺癌におけるNKX2-1/TTF-1遺伝子の不活性化突然変異および高メチル化

Author (18)： Matsubara Daisuke (Division of Integrative Pathology, Jichi Medical University, Shimotsukeshi, Japan) ,  Soda Manabu (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Yoshimoto Taichiro (Division of Integrative Pathology, Jichi Medical University, Shimotsukeshi, Japan) ,  Amano Yusuke (Division of Integrative Pathology, Jichi Medical University, Shimotsukeshi, Japan) ,  Sakuma Yuji (Division of Integrative Pathology, Jichi Medical University, Shimotsukeshi, Japan) ,  Yamato Azusa (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Ueno Toshihide (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kojima Shinya (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Shibano Tomoki (Division of Thoracic Surgery, Jichi Medical University, Shimotsukeshi, Japan) ,  Hosono Yasuyuki (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kawazu Masahito (Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Yamashita Yoshihiro (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Endo Shunsuke (Division of Thoracic Surgery, Jichi Medical University, Shimotsukeshi, Japan) ,  Hagiwara Koichi (Division of Respiratory Medicine, Jichi Medical University, Shimotsukeshi, Japan) ,  Fukayama Masashi (Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Takahashi Takashi (Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Mano Hiroyuki (Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Niki Toshiro (Division of Integrative Pathology, Jichi Medical University, Shimotsukeshi, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 9  Page： 1888-1896  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *adenocarcinoma ,...
Semi thesaurus term： EGFR gene mutation ,...

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Author keywords (5)： HNF4-α ,  hypermethylation ,  NKX2-1 mutation ,  non-TRU type ,  TTF-1

JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Genetic variation  (EC01030Y)

Reference (26)：

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• Jemal A, Siegel R, Ward E et al. Cancer statistics, 2006. CA Cancer J Clin 2006; 56: 106-30.
• Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK. Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer 2014; 14: 535-46.
• Yatabe Y, Mitsudomi T, Takahashi T. TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol 2002; 26: 767-73.
• Yatabe Y, Kosaka T, Takahashi T, Mitsudomi T. EGFR mutation is specific for terminal respiratory unit type adenocarcinoma. Am J Surg Pathol 2005; 29: 633-9.

Terms in the title (7)： 肺 ,  細胞型 ,  肺腺癌 ,  遺伝子 ,  不活性化 ,  突然変異 ,  メチル化