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J-GLOBAL ID：201702287587268779   Reference number：17A0601493

Nucleotide substitutions in CD101, the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes

1型糖尿病患者における非肥満糖尿病マウスの糖尿病感受性遺伝子のヒトホモログCD101におけるヌクレオチド置換

Author (41)： Okuno Misako (Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Okuno Misako (Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan) ,  Okuno Misako (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Kasahara Yoshihito (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Kasahara Yoshihito (Department of Pediatrics, Kanazawa University, Kanazawa, Japan) ,  Onodera Masafumi (Department of Human Genetics, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Takubo Noriyuki (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Takubo Noriyuki (Department of Pediatrics, Juntendo University, Tokyo, Japan) ,  Okajima Michiko (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Okajima Michiko (Department of Pediatrics, Kanazawa University, Kanazawa, Japan) ,  Suga Shigeru (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Suga Shigeru (Department of Pediatrics, National Hospital Organization Mie Hospital, Tsu, Japan) ,  Watanabe Nobuyuki (Department of Human Genetics, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Suzuki Junichi (Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Suzuki Junichi (Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan) ,  Suzuki Junichi (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Ayabe Tadayuki (Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Ayabe Tadayuki (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Urakami Tatsuhiko (Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan) ,  Urakami Tatsuhiko (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Kawamura Tomoyuki (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Kawamura Tomoyuki (Department of Pediatrics, Osaka City University, Osaka, Japan) ,  Kikuchi Nobuyuki (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Kikuchi Nobuyuki (Department of Pediatrics, Yokohama City Minato Red Cross Hospital, Yokohama, Japan) ,  Yokota Ichiro (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Yokota Ichiro (Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Shikoku Medical Center for Children and Adults, Zentsuji, Japan) ,  Kikuchi Toru (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Kikuchi Toru (Department of Pediatrics, Saitama Medical University, Saitama, Japan) ,  Amemiya Shin (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Amemiya Shin (Department of Pediatrics, Saitama Medical University, Saitama, Japan) ,  Nakabayashi Kazuhiko (Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Hayashi Keiko (Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Hata Kenichiro (Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Matsubara Yoichi (Department of Institute Director, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Ogata Tsutomu (Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Ogata Tsutomu (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Ogata Tsutomu (Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Fukami Maki (Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan) ,  Fukami Maki (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Sugihara Shigetaka (The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes, Kanazawa, Japan) ,  Sugihara Shigetaka (Department of Pediatrics, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan)
Material： Journal of Diabetes Investigation (Web)  (JDI (Web))
Volume： 8  Issue： 3  Page： 286-294  Publication year： 2017 
JST Material Number： U0507A  ISSN： 2040-1124  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *type 1 diabetes mellitus ,...
Semi thesaurus term： non-obese diabetic mice ,...

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Author keywords (3)： Disease susceptibility ,  Exome ,  Mutation

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Molecular genetics in general  (EC02010J)

Reference (24)：

• Morran MP, Vonberg A, Khadra A, et al. Immunogenetics of type 1 diabetes mellitus. Mol Aspects Med 2015; 42: 42-60.
• Santin I, Eizirik DL. Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis. Diabetes Obes Metab 2013; 15(Suppl 3): 71-81.
• Precechtelova J, Borsanyiova M, Sarmirova S, et al. Type I diabetes mellitus: genetic factors and presumptive enteroviral etiology or protection. J Pathog 2014; 2014: 738512.
• Groop L, Pociot F. Genetics of diabetes-are we missing the genes or the disease? Mol Cell Endocrinol 2014; 382: 726-739.
• Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461: 747-753.

Terms in the title (9)： 1型糖尿病 ,  患者 ,  非肥満糖尿病マウス ,  糖尿病 ,  感受性遺伝子 ,  ヒト ,  ホモログ ,  ヌクレオチド ,  置換