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J-GLOBAL ID：201702288344314033   Reference number：17A1099775

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

ERストレス蛋白質CHOP調節脂肪組織マクロファージ極性によるインスリン抵抗性を仲介する【Powered by NICT】

Author (18)： Suzuki Toru (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Gao Junhong (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Gao Junhong (Tohoku University International Advanced Research and Education Organization, Frontier Research Institute for Interdisciplinary Science, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan) ,  Ishigaki Yasushi (Division of Diabetes and Metabolism, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan) ,  Kondo Keiichi (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Sawada Shojiro (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Izumi Tomohito (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Uno Kenji (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Kaneko Keizo (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Tsukita Sohei (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Takahashi Kei (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Asao Atsuko (Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Ishii Naoto (Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Imai Junta (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Yamada Tetsuya (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Oyadomari Seiichi (Division of Molecular Biology, Institute for Genome Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan) ,  Katagiri Hideki (Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan) ,  Katagiri Hideki (Agency for Medical Research and Development-Core Research for Evolutional Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-1004, Japan)
Material： Cell Reports
Volume： 18  Issue： 8  Page： 2045-2057  Publication year： 2017 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Obesity represents chronic inf...

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Thesaurus term： *ER stress ,  down-regulation ,  up-regulation ,  Th2 cell ,  inflammation ,  *insulin resistance ,  high fat diet ,  *polarity ,  *macrophage ,  obesity ,  fat cell
Semi thesaurus term： 分子機構 ,  Th2サイトカイン ,  白色脂肪組織 ,  *CHOP , 【Automatic Indexing@JST】

Author keywords (5)： ER stress ,  adipose tissue macrophage ,  macrophage polarization ,  insulin resistance ,  M2 macrophage

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Fruits and processed fruit products  (FJ11030Z) ,  Animal metabolism and nutrition in general  (EJ02031R)

Terms in the title (8)： ERストレス ,  蛋白質 ,  調節 ,  脂肪組織 ,  マクロファージ ,  極性 ,  インスリン抵抗性 ,  仲介