Art

J-GLOBAL ID：201702288401263579   Reference number：17A1228347

Recombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro

組換ヒトトロンボモジュリンはin vitroにおいて好中球細胞外トラップ形成を阻害する

Author (12)： SHIMOMURA Yasuyo (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  SUGA Mika (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  KURIYAMA Naohide (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  KURIYAMA Naohide (Harvard Medical School, MA, USA) ,  NAKAMURA Tomoyuki (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  SAKAI Toshikazu (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  KATO Yu (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  HARA Yoshitaka (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  YAMASHITA Chizuru (Fujita Health Univ. School of Medicine, Aichi, JPN) ,  NAGASAKI Hiroshi (Fujita Health Univ. School of Medicine, Toyoake, JPN) ,  KANEKI Masao (Harvard Medical School, MA, USA) ,  NISHIDA Osamu (Fujita Health Univ. School of Medicine, Aichi, JPN)
Material： Journal of Intensive Care (Web)
Volume： 4  Issue： July  Page： 4:48 (WEB ONLY)  Publication year： Jul. 2016 
JST Material Number： U1116A  ISSN： 2052-0492  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Thrombomodulin ,...
Semi thesaurus term： cell component ,...

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JST classification (2)： Basic hematology  (GK01020N) ,  Basic research of drugs acting on blood and body fluid  (GW14010M)

Reference (12)：

• Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532-5.
• Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med. 2007;13:463-9.
• Ohlin AK, Larsson K, Hansson M. Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma. J Thromb Haemost. 2005;3:976-92.
• Schouten M, Wiersinga WJ, Levi M, van der Poll T. Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol. 2008;83:536-45.
• Yamakawa K, Ogura H, Fujimi S, Morikawa M, Ogawa Y, Mohri T, et al. Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. Intensive Care Med. 2013;39:644-52.

Terms in the title (5)： 組換 ,  ヒト ,  トロンボモジュリン ,  好中球細胞外トラップ ,  阻害