Art

J-GLOBAL ID：201702291599433526   Reference number：17A0791344

Topical application of nitrosonifedipine, a novel radical scavenger, ameliorates ischemic skin flap necrosis in a mouse model

新しいラジカル消去剤であるニトロソニフェジピンの局所投与はマウスモデルの虚血性皮膚弁壊死を改善する

Author (11)： Fukunaga Yutaka (Department of Plastic and Reconstructive Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Izawa-Ishizawa Yuki (Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Horinouchi Yuya (Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Sairyo Eriko (Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Ikeda Yasumasa (Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Ishizawa Keisuke (Department of Pharmacy, Tokushima University Hospital) ,  Ishizawa Keisuke (Department of Clinical Pharmacy, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Tsuchiya Koichiro (Department of Medical Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan) ,  Abe Yoshiro (Department of Plastic and Reconstructive Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Hashimoto Ichiro (Department of Plastic and Reconstructive Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School) ,  Tamaki Toshiaki (Department of Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School)
Material： Wound Repair and Regeneration  (Wound Repair Regen)
Volume： 25  Issue： 2  Page： 217-223  Publication year： Mar. 2017 
JST Material Number： W1433A  ISSN： 1067-1927  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： scavenger ,...
Semi thesaurus term： Radical Scavengers ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0791344&from=J-GLOBAL&jstjournalNo=W1433A") }}

JST classification (2)： Basic dermatology  (GF01020Y) ,  Basic research of other drugs  (GW23010K)

Substance index (2)： Nitrosonifedipine ,  Malondialdehyde

Reference (32)：

• Suzuki S, Matsushita Y, Isshiki N, Hamanaka H, Miyachi Y. Salvage of distal flap necrosis by topical superoxide dismutase. Ann Plast Surg 1991; 27: 253-7.
• Im MJ, Manson PN, Bulkley GB, Hoopes JE. Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. Ann Surg 1985; 201: 357-9.
• Ashoori F, Suzuki S, Zhou J, Nishigaki I, Takahashi R. Possible contributions of mastocytosis, apoptosis, and hydrolysis in pathophysiology of randomized skin flaps in humans and guinea pigs. Plast Reconstr Surg 1996; 98: 491-501.
• Emekli U, Tuncer S, Kabakas F, Aydin A, Arinci A, Bilgic B, et al. The effect of short- versus long-term administration of alpha tocopherol on the survival of random flaps in experimental diabetes mellitus. J Diabetes Complicat 2004; 18: 249-57.
• Edmunds M-CC, Czopek A, Wigmore SJ, Kluth DC. Paradoxical effects of heme arginate on survival of myocutaneous flaps. Am J Physiol Regul Integr Comp Physiol 2014; 306 (1): R10-22.

Terms in the title (6)： ラジカル消去剤 ,  ニトロソニフェジピン ,  局所投与 ,  マウスモデル ,  虚血 ,  皮膚弁壊死