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J-GLOBAL ID：201702296293887101   Reference number：17A0864329

HTLV-1関連疾患の診断と治療の進歩 VIII.HTLV-1関連疾患に対する新規治療法の展望

Author (2)： FUKUSHIMA NORIYASU (広島大 原爆放射線医科研 血液・腫瘍内科研究分野) ,  ICHINOHE TATSUO (広島大 原爆放射線医科研 血液・腫瘍内科研究分野)
Material： 日本内科学会雑誌  (Journal of the Japanese Society of Internal Medicine)
Volume： 106  Issue： 7  Page： 1417-1422  Publication year： Jul. 10, 2017 
JST Material Number： F0916A  ISSN： 0021-5384  CODEN： NNGAA  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： molecular targeting drug ,...
Semi thesaurus term： anti CCR4 antiboy ,...

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JST classification (3)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Experimental treatment for tumors  (GE02040Y)

Substance index (2)： KW-0761 ,  CC-5013

Reference (10)：

• 1) Ishida T, et al: Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30: 837-842, 2012.
• 2) Ishida T, et al: Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study. Br J Haematol 169: 672-682, 2015.
• 3) Ureshino H, et al: Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T-cell leukemia. Cancer Immunol Res 4: 644-649, 2016.
• 4) Ito T, et al: Identification of a primary target of thalidomide teratogenicity. Science 327: 1345-1350, 2010.
• 5) Ishida T, et al: Multicenter phase II study of lenalidomide in relapsed or recurrent adult T-cell leukemia/lymphoma: ATLL-002. J Clin Oncol 34: 4086-4093, 2016.

Terms in the title (6)： HTLV-1 ,  疾患 ,  診断 ,  治療 ,  治療法 ,  展望