Chem
J-GLOBAL ID：201707003155608074   Nikkaji number：J3.628.138C

Larotrectinib

ラロトレクチニブ
Substance type：
Substance type
Substance type classified into 3 categories.
Decided structure: Substances with a clear structure
Undicided Structure: Substances with unknown or undetermined structure
Mixtures: Mixtures, racemic compounds, or compounds with relative structural arrangements
Decided structure
Molecular formula： C21H22F2N6O2
Molecular formula furigana： C21-H22-F2-N6-O2
Molecular weight： 428.444
InChI： InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
InChI key： NYNZQNWKBKUAII-KBXCAEBGSA-N
SMILES： O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Systematic name  (3)：
  • (3S)-N-[5-[(2R)-2-(2,5-ジフルオロフェニル)-1-ピロリジニル]-ピラゾロ[1,5-a]ピリミジン-3-イル]-3-ヒドロキシ-1-ピロリジンカルボアミド
  • (3S)-N-{5-[(2R)-2-(2,5-ジフルオロフェニル)ピロリジン-1-イル]ピラゾロ[1,5-a]ピリミジン-3-イル}-3-ヒドロキシピロリジン-1-カルボキサミド
  • (3S)-N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine-1-carboxamide
Other name (5)：
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]-pyrazolo[1,5-a]pyrimidine-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide
  • ラロトレクチニブ
  • Larotrectinib
  • LOXO-101
  • ARRY-470
CAS registry number： 1223403-58-4
Application (2)：
antitumor drug ,  molecular targeting drug
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