Ikawa Tomokatsu

イカワトモカツ | Ikawa Tomokatsu

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.ribs.tus.ac.jp/index.php/institute/labforres/ikawalab/

Research field (1)： Immunology

Research keywords (8)： T cell development, B cell development, hematopoietic stem cell, epigenetics , Hematopoiesis , Hematopoietic stem cell , Transcriptional regulation , Epigenetics , B cell differentiation , T cell differentiation , Immunology

Research theme for competitive and other funds (13)：

2019 - 2022 Roles of a non-coding RNA that regulates normal and neoplastic T cell development
2018 - 2020 Dissection of immune cell differentiation by a single cel epigenome analysis
2017 - 2020 Role of Polycomb proteins in lymphocyte cell fate decision
2017 - 2020 Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment
2016 - 2018 SIngle-cell transcriptional networks during B cell differentiation

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Papers (56)：

Uehata T, Yamada S, Ori D, Vandenbon A, Giladi A, Jelinski A, Murakawa Y, Watanabe H, Takeuchi K, Toratani K, Mino T, Kiryu H, Standley DM, Tsujimura T, Ikawa T, Kondoh G, Landthaler M, Kawamoto H, Rodewald HR, Amit I, Yamamoto R, Miyazaki M and Takeuchi O. Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. BLOOD. 2024. 143. 3. 243-257
Kondo S, Nomura M, Kato S, Zang W, Akashi T, Viny A, Fukumoto M, Shigehiro T, Ikawa T, Yamazaki H, Tanaka A, Zhang Y, Nishimura K, Hayashi Y, Koike Y, Aoyama Y, Nishikawa H, Kitamura T, Kanai A, Yokoyama A, Fujiwara T, Noguchi H, Lee SC, Toyoda A, Hinohara K, Abdel-Wahab O and Inoue D. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin looping. Nature Communications. 2023. 14. 1. 8372
Yaeko Nakajima-Takagi, Motohiko Oshima, Junichiro Takano, Shuhei Koide, Naoki Itokawa, Shun Uemura, Masayuki Yamashita, Shohei Andoh, Kazumasa Aoyama, Yusuke Isshiki, et al. Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. eLife. 2023. 12. e83004
Jin J, Ogawa T, Hojo N, Kryukov K, Shimiz K, Ikawa T, Imanishi T, Okazaki T, and Shiroguchi K. Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic phenotypes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023. 2210283120. e2210283120. e2210283120
Yosuke Nagahata, Kyoko Masuda, Yuji Nishimura, Tomokatsu Ikawa, Shinpei Kawaoka, Toshio Kitawaki, Yasuhito Nannya, Seishi Ogawa, Hiroshi Suga, Yutaka Satou, et al. Tracing the evolutionary history of blood cells to the unicellular ancestor of animals. Blood. 2022. 140. 24. 2611-2625

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MISC (14)：

伊川友活. 転写因子とマクロファージ分化. 臨床免疫・アレルギー科. 2021. 75. 699-706
藥師寺那由他, 伊川友活. B細胞分化を駆動する転写プログラムとクロマチン制御. 臨床免疫・アレルギー科. 2019. 71. 215-222
宮井智浩, 伊川友活. 多能性前駆細胞からB細胞への分化における段階的転写制御. 臨床免疫・アレルギー科. 2018. 70. 503-513
Bidisha Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Kiyoshi Ando, Arinobu Tojo, Hiroshi Kawamoto, Ai Kotani. EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage. BLOOD. 2014. 124. 21
Bidisha Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Kiyoshi Ando, Arinobu Tojo, Hiroshi Kawamoto, Ai Kotani. EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage. BLOOD. 2014. 124. 21

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Lectures and oral presentations (62)：

多能血液前駆細胞を用いた白血病研究・免疫細胞療法への応用
(第5回東京理科大学総合研究院合成生物学研究部門シンポジウム 2024)
多能血液前駆細胞の自己副性能を利用した免疫細胞療法の開発
(2023年度東京理科大学生命医科学研究所シンポジウム 2024)
Functional analysis of transcription factors PU.1 and SpiB in the determination of dendritic cell fate
(第52回日本免疫学会 2024)
Ectopic expressions of inflammatory cytokines promote the proliferation of B-precursor acute lymphoblastic leukemia
(第52回日本免疫学会 2024)
Polycomb group proteins PCGF2 and PCGF4 work together during erythrocyte and megakaryocyte differentiation
(第52回日本免疫学会 2024)

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Professional career (1)：

Ph.D (Kyoto University)

Committee career (3)：

2023/05/28 - 2028/06/18 Kyoto T Cell Conference administration officer
2021/01/01 - 2024/12/31 Japanese Society for Immunology councilor
2018/08 - 2022/08 Japanese Society of Interferon & Cytokine Research exective board

Association Membership(s) (3)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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