Kinoshita Akira

キノシタアキラ | Kinoshita Akira

Affiliation and department：

Research field (1)： Medical biochemistry

Research keywords (8)： Camurati-Engelmann Disease , TGF-beta 1 , bone , Gillespie syndrome , ITPR1 , proteasome , ear wax , interferon regulatory factor 6

Research theme for competitive and other funds (10)：

2023 - 2026 骨系統疾患治療のゲームチェンジャー:ヒストン修飾を標的にした治療法の開発
2019 - 2022 網羅的発現解析が明らかにした眼特異的転写産物は角膜再生の新規キープレーヤーか?
2015 - 2018 患者由来iPS細胞を用いたTGFシグナル異常骨系統疾患の治療法の開発
2012 - 2015 プロテアソーム不全と炎症疾患:細胞ストレスによる新たな発症機序の解明
2013 - 2014 カムラチー・エンゲルマン病の治療法の確立: 新規遺伝子探索、モデル構築、分子標的治療薬の探索

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Papers (107)：

Yuji Kobayashi, Koji Ando, Yoshitaka Imaizumi, Hikaru Sakamoto, Hideaki Kitanosono, Masataka Taguchi, Hiroyuki Mishima, Akira Kinoshita, Shara Bekytbek, Maki Baba, et al. RUNX1 expression is regulated by a super-enhancer and is a therapeutic target in adult T-cell leukemia/lymphoma. Leukemia & lymphoma. 2024. 1-13
Masaki Ibe, Shinobu Tamura, Hideki Kosako, Yusuke Yamashita, Masamichi Ishii, Masaoh Tanaka, Hiroyuki Mishima, Akira Kinoshita, Sadahiro Iwabuchi, Shuhei Morita, et al. Familial schwannomatosis carrying LZTR1 variant p.R340X with brain tumor: A case report. Molecular genetics and metabolism reports. 2024. 40. 101107-101107
Daisuke Hatta, Shiho Makiya, Kaito Kanamoto, Kaori Watanabe, Yuki Fuchigami, Shigeru Kawakami, Akira Kinoshita, Koh-Ichiro Yoshiura, Naohiro Kurotaki, Keiro Shirotani, et al. Proline-rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L-dopa-treated mice. Neuropsychopharmacology reports. 2024
Zheng Wang, Mitsuhiro Kometani, Leonid Zeitlin, Yael Wilnai, Akira Kinoshita, Koh-ichiro Yoshiura, Hiroko Ninomiya, Takeshi Imamura, Long Guo, Jingyi Xue, et al. Heterozygous mutations in the straitjacket region of the latency-associated peptide domain of TGFB2 cause Camurati-Engelmann disease type II. Journal of Human Genetics. 2024
Daisuke Hatta, Kaito Kanamoto, Shiho Makiya, Kaori Watanabe, Tatsuya Kishino, Akira Kinoshita, Koh-Ichiro Yoshiura, Naohiro Kurotaki, Keiro Shirotani, Nobuhisa Iwata. Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits. Journal of biochemistry. 2023

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MISC (62)：

木下晃. 特集小児遺伝子疾患事典骨系統疾患 TGFB1(関連疾患:Camurati-Engelmann病). 小児科診療. 2021. 84. 11. 1710-1711
北之園英明, 安東恒史, 今泉芳孝, 小林裕児, 三嶋博之, 木下晃, 田口正剛, 坂本光, 加藤丈晴, 佐藤信也, et al. Combination therapy of PRMT5 inhibitor and PHD2 inhibitor (IOX4) for adult T-cell leukemia/lymphoma. 日本血液学会学術集会抄録(Web). 2021. 83rd
小林裕児, 安東恒史, 今泉芳孝, 北之園英明, 三嶋博之, 木下晃, 田口正剛, 坂本光, 加藤丈晴, 佐藤信也, et al. RUNX1 as a therapeutic target for adult T-cell leukemia/lymphoma. 日本血液学会学術集会抄録(Web). 2021. 83rd
鳥越未来, 小畑陽子, 井上大, 鳥越健太, 木下晃, 小路武彦, 西野友哉. ヒドロキシクロロキンは抗GBM抗体腎炎の進展を抑制する. 日本腎臓学会誌. 2020. 62. 4. 310-310
Miki Torigoe, Yoko Obata, Hiro Inoue, Kenta Torigoe, Akira Kinoshita, Takehiko Koji, Tomoya Nishino. HYDROXYCHLOROQUINE PREVENTS ANTI-GBM GLOMERULONEPHRITIS IN RATS. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2020. 35. 663-663

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Education (1)：

1999 - 2002 Nagasaki University Graduate School of Biomedical Sciences

Work history (6)：

2022/01 - 現在 Nagasaki University Atomic Bomb Disease Institute
2012 - 2021 Nagasaki University
2011 - 2012/03 Nagasaki University Graduate School of Biomedical Sciences
2007 - 2011 Nagasaki University Graduate School of Biomedical Sciences
2005 - 2007 University of Iowa Department of Pediatrics Postdoctoral fellow

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Committee career (1)：

2016 - 現在日本人類遺伝学会評議委員

Awards (1)：

2001/10 - 日本人類遺伝学会奨励賞

Association Membership(s) (3)：

The American Society of Human Genetics , The Japanese Society for Gene Diagnosis and Therapy , THE JAPAN SOCIETY OF HUMAN GENETICS

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