Yuu Miyauchi

ミヤウチユウ | Yuu Miyauchi

Affiliation and department：
Job title：講師

Research field (2)： Pharmaceuticals - health and biochemistry , Pharmaceuticals - health and biochemistry

Research keywords (5)：衛生薬学 , 薬物代謝 , タンパク質間相互作用 , 小胞体 , 核内受容体

Research theme for competitive and other funds (13)：

2023 - 2025 UDP-グルクロン酸転移酵素の細胞質ペプチドによる空間を超えた酵素活性の制御: 膜脂質との相互作用
2022 - 2024 シトクロムP450による肝障害惹起の機構解明:終末糖化産物に対する感受性の上昇
2023 - 2024 糖化産物スカベンジャー受容体の包括的解析:炎症シグナル抑制に向けた基盤構築
2022 - 2023 シトクロムP450による肝毒性発現の機構解明:終末糖化産物に対する感受性の上昇
2020 - 2023 Suppression of oxidative stress by protein-protein interaction between cytochrome P450 and UDP-glucuronosyltransferase

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Papers (21)：

Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi. Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products. The Journal of toxicological sciences. 2023. 48. 5. 263-272
Madoka Sawai, Yuu Miyauchi, Takumi Ishida, Shinji Takechi. Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of Toxicological Sciences. 2022. 47. 9. 381-387
Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I Mackenzie, Yuji Ishii. Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in pharmacology. 2022. 13. 832931-832931
Shoji Nakamura, Ryohei Yamashita, Yuu Miyauchi, Yoshitaka Tanaka, Yuji Ishii. Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems. 2021. 51. 11. 1-25
Hong-Bin Chen, Jorge Carlos Pineda Garcia, Shinako Arizono, Tomoki Takeda, Ren-Shi Li, Yukiko Hattori, Hiroe Sano, Yuu Miyauchi, Yuko Hirota, Yoshitaka Tanaka, et al. DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Scientific reports. 2021. 11. 1. 18532-18532

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MISC (11)：

宮内優. 奨励賞を受賞して. 日本薬物動態学会ニュースレター. 2022. 37. 6
Yuu Miyauchi. [Protein-Protein Interactions as Underlying Regulatory Mechanisms of Drug-metabolizing Enzyme Function]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2022. 142. 11. 1169-1175
宮内優. 万病のもと「糖化産物」:生命にとって不可欠な糖がもたらすリスク. 環境・衛生薬学トピックス. 2022
宮尾宏哉, 塩路優子, 宮内優, 武田知起, 武田知起, 田中嘉孝, 石井祐次. Aryl hydrocarbon receptor(AHR)欠損ラットにおける低尿酸血症の詳細機構の解明:核酸代謝に着目した検討. 日本薬学会九州支部大会講演要旨集. 2021. 38th (CD-ROM)
Yuu Miyauchi, Shinji Takechi, Yuji Ishii. Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological & pharmaceutical bulletin. 2021. 44. 11. 1635-1644

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Lectures and oral presentations (4)：

Investigation of the function of UDP-glucuronosyltransferase focusing on its enzymatic features: C-terminal cytoplasmic peptide and oligomer formation
(PRIS 2023 in 2023 ICCP450/JSSX International Joint Meeting (Educational Lecture) 2023)
Functional interactions between different drug-metabolizing enzymes: a novel approach for variance in CYP3A4 activity
(2022)
タンパク質間相互作用による薬物代謝酵素の制御機構
(第38回日本薬学会九州支部大会(受賞講演) 2021)
UDP-グルクロン酸転移酵素研究の基盤: 小胞体局在機構、機能発現、およびシトクロムP450機能調節
(フォーラム2021衛生薬学・環境トキシコロジー(受賞講演) 2021)

Education (3)：

2012 - 2015 九州大学大学院薬学府創薬科学専攻博士後期課程
2010 - 2012 九州大学大学院薬学府創薬科学専攻修士課程
2006 - 2010 Kyushu University School of Pharmaceutical Sciences

Professional career (2)：

修士(創薬科学) (九州大学大学院薬学府)
博士(創薬科学) (九州大学大学院薬学府)

Work history (4)：

2020/04 - 現在 Faculty of Pharmaceutical Sciences, Sojo University Laboratory of Hygienic Chemistry Senior Assistant Professor
2016/11 - 2020/03 Kyushu University Faculty of Pharmaceutical Sciences
2015/05 - 2016/11 National Institute of Environmental Health Sciences (NIEHS) Pharmacogenetics Group Visiting Fellow
2015/04 - 2015/04 Kyushu University Faculty of Pharmaceutical Sciences

Committee career (1)：

2021/04 - 2023/03 日本薬学会「ファルマシア」トピックス小委員

Awards (9)：

2022/12 - 崇城大学令和3年度ベストリサーチアワード
2022/11 - The Japanese Society for the Study of Xenobiotics JSSX Award for Young Scientists
2022/07 - 崇城大学令和3年度ベストティーチング賞
2021/11 - 日本薬学会九州山口支部学術奨励賞
2021/09 - 日本薬学会環境・衛生部会部会賞・金原賞

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Association Membership(s) (5)：

American Society for Pharmacology and Experimental Therapeutics , International Society for the Study of Xenobiotics , THE JAPANESE SOCIETY OF TOXICOLOGY , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE PHARMACEUTICAL SOCIETY OF JAPAN

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