Rchr
J-GLOBAL ID:201801000278724954
Update date: Jan. 01, 2024
NAKAGAWA Osamu
ナカガワ オサム | NAKAGAWA Osamu
Research field (3):
Pharmaceuticals - chemistry and drug development
, Chemical biology
, Biochemistry
Research keywords (4):
Nucleic Acid Chemistry
, Oligonucleotide Therapeutics
, Bioorganic Chemistry
, Organic Chemistry
Research theme for competitive and other funds (6):
Papers (57):
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Yamaji R, Nakagawa O, Kishimoto Y, Fujii A, Matsumura T, Nakayama T, Kamada H, Osawa T, Yamaguchi T, Obika S. Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides. Bioorganic & Medicinal Chemistry. 2022. 72. 116972
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Kishimoto Y, Fujii A, Nakagawa O, Obika S. Enhanced Duplex- and Triplex-forming Ability and Enzymatic Resistance of Oligodeoxynucleotides Modified by a Tricyclic Thymine Derivative. Organic & Biomolecular Chemistry. 2021. 19. 37. 8063-8074
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Nakagawa O, Aoyama H, Fujii A, Kishimoto Y, Obika S. Crystallographic Structure of Novel Types of AgI-Mediated Base Pairs in Non-canonical DNA Duplex Containing 2′-O,4′-C-Methylene Bridged Nucleic Acids. Chemistry - A European Journal. 2021. 27. 11. 3842-3848
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Kishimoto Y, Nakagawa O, Fujii A, Yoshioka K, Nagata T, Yokota T, Hari Y, Obika S. 2′,4′-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance**. Chemistry - A European Journal. 2021. 27. 7. 2427-2438
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Funai T, Tagawa C, Nakagawa O, Ono A, Wada S, Urata H. Enzymatic formation of consecutive thymine-HgII-thymine base pairs by DNA polymerases. Chemical Communications. 2020. 56. 12025-12028
more...
Patents (2):
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Method for quantitatively detecting 8-oxo-2'-deoxyguanosine in aqueous sample solution with high sensitivity, and fluorescent probe molecule
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Targeted Intercellular Delivery of Oligonucleotides via Conjugation with Small Molecule Ligands
Books (5):
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REDUCT-siRNA:プロドラッグ型siRNAによる優れた遺伝子発現抑制効果
生産と技術, 68, 72-76, 生産技術振興協会 2016
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化学的アプローチを駆使した核酸医薬の最前線
遺伝子医学 MOOK, 30, 125-131, メディカルドゥ 2016
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遺伝子の損傷診断・発現抑制・デリバリーを統合的に機能化する人工核酸の開発
薬学雑誌, 134, 1319-1329, 日本薬学会 2014
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動的コンビナトリアルケミストリーによるDNA結合分子の探索
ファルアシア, 42, 938-939, 日本薬学会 2006
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核酸をトリガーとする増幅反応
化学, 60, 70-71, 化学同人 2005
Lectures and oral presentations (124):
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Synthesis and in vivo evaluation of 9-aminoethoxy-1,3-diaza-2-oxophenoxazine conjugated antisense oligonucleotides
(The 48th International Symposium on Nucleic Acids Chemistry (ISNAC2021), The 5th Annual Meeting of Japan Society of Nucleic Acids Chemistry 2021)
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DNAやRNAを用いた新しい医薬品
(徳島文理高等学校 (令和3年度キャリア教育推進事業 (高校1年生) 第2回) 2021)
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9-アミノエトキシフェノキサジンコンジュゲートオリゴ核酸の合成と評価
(日本薬学会 第140年会 2020)
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9-アミノエトキシフェノキサジン塩基を有するグリコール核酸の合成と評価
(日本薬学会 第140年会 2020)
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Evaluation of oligodeoxynucleotides containing tricyclic 2-oxobenzo[b][1,8]naphthyridine that targets adenine nucleobase
(The 100th Annual Meeting 2020 of CSJ 2020)
more...
Education (1):
- 2001 - 2004 Osaka University Graduate School of Pharmaceutical Sciences
Professional career (1):
Work history (7):
- 2021/04 - 2021/12 Osaka University Graduate School of Pharmaceutical Sciences Guest Associate Professor
- 2020/04 - 2021/12 Tokushima Bunri University Faculty of Pharmaceutical Sciences Associate Professor
- 2014/04 - 2020/03 Osaka University Graduate School of Pharmaceutical Sciences Specially Appointed Associate Professor
- 2011/08 - 2014/03 Osaka University of Pharmaceutical Sciences Research Associate
- 2009/04 - 2011/07 The University of North Carolina at Chapel Hill UNC Eshelman School of Pharmacy Postdoctoral Research Associate
- 2007/04 - 2009/03 Kyushu University Graduate School of Pharmaceutical Sciences Assistant Professor
- 2004/04 - 2007/03 Kyushu University Graduate School of Pharmaceutical Sciences Research Associate
Show all
Awards (1):
- 2014/01 - The Pharmaceutical Society of Japan Kansai Branch, Award for Young Scientists
Association Membership(s) (2):
The Pharmaceutical Society of Japan
, The Chemical Society of Japan
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