Rchr
J-GLOBAL ID:201801000287031457
Update date: Nov. 02, 2024
Tanaka Yoshio
Tanaka Yoshio
Affiliation and department:
Job title:
Professor
Research field (1):
Pharmacology
Research keywords (5):
n-3 unsaturated fatty acid
, BK channel
, urinary bladder smooth muscle
, Smooth muscle contraction/relaxation mechamism
, adrenoceptor
Research theme for competitive and other funds (22):
- 2024 - 2027 n-3系PUFAはストア作動性Caチャネルを標的として気管平滑筋の収縮を抑制する
- 2024 - 2027 フェルラ酸は血小板活性化因子(PAF)による膀胱平滑筋の過活動を改善する
- 2023 - 2026 α-リノレン酸は脳動脈収縮を即時的かつDHA・EPAに匹敵するほど強力に抑制する
- 2021 - 2024 下部泌尿器平滑筋の収縮機能異常に対するγ-リノレン酸の抑制効果の分子基盤
- 2020 - 2023 Mechanisms which underlie the immediate inhibitory effects by n-3 polyunsaturated fatty acids of coronary artery contraction
- 2011 - 2013 Unexpected pharmacological effects of n-3 polyunsaturated fatty acids (PUFAs): A new mechanism by which n-3 PUFAs produce blood vessel relaxation
- 2008 - 2010 Atypical beta-adrenoceptor in vascular smooth muscle : studies on the sensitivity to bupranolol and the effects of sympathetic nerve denervation
- 2008 - 2008 血管平滑筋のβ受容体の発現特異性と変動性:部位差・加齢の視点からの解析
- 2006 - 2007 Pharmacological identification of vascular smooth muscle β-adrenoceptors and clarification. of1heir physiological roles
- 2006 - 2007 Studies on the finictional coupling between β3-adtenoceptor and MaxiK channel in urinary bladder smooth muscle
- 2002 - 2003 Physiological roles of MaxiK channel in the regulation of smooth muscle mechanical activity and the new insights into the molecular mechanisms responsible for MaxiK channel-mediated responses
- 2000 - 2001 Mechanisms responsible for MaxiK_<Ca> channel-mediated vascular relaxation
- 1998 - 1999 血管作働性物質によるマキシK_<Ca>チャネル修飾機構の分子機序と生理的意義
- 1998 - 1999 NO関連物質によるマキシK^+チャネル活性化の分子機構と生理的意義
- 1994 - 1994 血管の動力学的刺激-機能発現過程におけるチロシンキナーゼによる特異的調節機構
- 1994 - 1994 脈管系におけるバイオメカニクス反応と薬物による制御
- 1993 - 1993 筋ジストロフィーマウスを用いた循環系のメカノセンサー機構に関わる分子薬理的研究
- 1993 - 1993 血管〓縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序
- 1992 - 1993 Sutudy of vascular reactions in response to hemodynamic factors assessed by stretch activation
- 1992 - 1992 血管攣縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序
- 1990 - 1991 Coupling mechanism of mechano-sensing and cellular reactivity in the process of stretch activation of vascular tissue.
- 1988 - 1989 Study of the stimulus-response relationship in a multi-cellular system by use of stretch-induced contractile activation of vascular tissue.
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Papers (186):
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Keisuke Obara, Kento Yoshioka, Yoshio Tanaka. Platelet-activating Factor (PAF) in Urinary Bladder Smooth Muscle (UBSM): Its Novel Role as a Potential Inducer of Detrusor Overactivity and the Mechanisms Underlying Its Effects in Enhancing UBSM Mechanical Activities. YAKUGAKU ZASSHI. 2024. 144. 11. 997-1007
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Keisuke Obara, Yuki Usami, Risa Okamoto, Kento Yoshioka, Yoshio Tanaka. Evaluation of inhibitory actions of antidepressants on muscarinic receptors assessed by a binding assay in the mouse cerebral neocortex. Journal of Pharmacological Sciences. 2024
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Keisuke Obara, Kento Yoshioka, Yoshio Tanaka. Effects of Platelet-Activating Factor (PAF) on the Mechanical Activities of Lower Urinary Tract and Genital Smooth Muscles. Biological and Pharmaceutical Bulletin. 2024. 47. 9. 1467-1476
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Kento Yoshioka, Keisuke Obara, Mikoto Ozawa, Mayu Kiguchi, Yuri Nakao, Hinako Miyaji, Toma Yamashita, Noboru Saitoh, Yutaka Nakagome, Yoshio Tanaka. Alpha-linolenic acid selectively inhibits the contraction of pig coronary arteries mediated through prostanoid TP receptors. Journal of pharmacological sciences. 2024. 155. 4. 148-151
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Keyue Xu, Miyuki Shimizu, Toma Yamashita, Mako Fujiwara, Shunya Oikawa, Guanghan Ou, Naho Takazakura, Taichi Kusakabe, Keisuke Takahashi, Keisuke Kato, et al. Inhibitory mechanisms of docosahexaenoic acid on carbachol-, angiotensin II-, and bradykinin-induced contractions in guinea pig gastric fundus smooth muscle. Scientific reports. 2024. 14. 1. 11720-11720
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MISC (168):
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藤井 彩乃, 小原 圭将, 八巻 史子, 田中 芳夫. 各種統合失調症治療薬のアセチルコリンエステラーゼ(AChE)活性阻害作用の検討. 応用薬理. 2018. 94. 5-6. 101-101
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鶴岡 優里, 山岸 理沙, 曽根 知世, 山崎 玖美, 茅野 大介, 椎名 俊介, 小原 圭将, 八巻 史子, 檜貝 孝慈, 田中 芳夫. イソプレナリンによるモルモット結腸縦走筋の弛緩反応にはβ1とβ3-アドレナリン受容体が関与する. 応用薬理. 2018. 94. 5-6. 115-115
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小原 圭将, 今中 智子, 福原 央香, 宇野 準二, 茅野 大介, 田中 芳夫. 雌性モルモットの近位および遠位尿道でのノルアドレナリンの収縮作用に対する各種抗うつ薬の影響. 日本薬学会年会要旨集. 2016. 136年会. 3. 68-68
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椎名 俊介, 橋本 瑛里, 小原 圭将, 茅野 大介, 田中 芳夫. ラット胸部大動脈のβ-アドレナリン受容体(β-ADR)を介した弛緩反応に関するK+チャネル分子種の薬理学的同定. 日本薬学会年会要旨集. 2016. 136年会. 3. 178-178
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Kyosuke Sato, Nanako Nishioka, Keisuke Kanai, Mika Aoki, Keisuke Obara, Daisuke Chino, Yoshio Tanaka. ISignificant roles for K+ channels and cytochrome P450 (CYP) epoxygenase metabolites in the relaxant effects of docosahexaenoic acid (DHA) on the rat thoracic aorta contracted with TXA(2) receptor (TP receptor) stimulation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 159P-159P
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Professional career (1):
Association Membership(s) (3):
JAPAN SOCIETY OF SMOOTH MUSCLE RESEARCH
, THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
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