Rchr
J-GLOBAL ID：201801000287031457
Update date: Feb. 03, 2024
Tanaka Yoshio
Tanaka Yoshio
Affiliation and department：
Job title：
Professor
Research field (1)：
Pharmacology
Research keywords (5)：
n-3 unsaturated fatty acid
, BK channel
, urinary bladder smooth muscle
, Smooth muscle contraction/relaxation mechamism
, adrenoceptor
Research theme for competitive and other funds (20)：
- 2023 - 2026 α-リノレン酸は脳動脈収縮を即時的かつDHA・EPAに匹敵するほど強力に抑制する
- 2021 - 2024 下部泌尿器平滑筋の収縮機能異常に対するγ-リノレン酸の抑制効果の分子基盤
- 2020 - 2023 Mechanisms which underlie the immediate inhibitory effects by n-3 polyunsaturated fatty acids of coronary artery contraction
- 2011 - 2013 Unexpected pharmacological effects of n-3 polyunsaturated fatty acids (PUFAs): A new mechanism by which n-3 PUFAs produce blood vessel relaxation
- 2008 - 2010 Atypical beta-adrenoceptor in vascular smooth muscle : studies on the sensitivity to bupranolol and the effects of sympathetic nerve denervation
- 2008 - 2008 血管平滑筋のβ受容体の発現特異性と変動性:部位差・加齢の視点からの解析
- 2006 - 2007 Pharmacological identification of vascular smooth muscle β-adrenoceptors and clarification. of1heir physiological roles
- 2006 - 2007 Studies on the finictional coupling between β3-adtenoceptor and MaxiK channel in urinary bladder smooth muscle
- 2002 - 2003 Physiological roles of MaxiK channel in the regulation of smooth muscle mechanical activity and the new insights into the molecular mechanisms responsible for MaxiK channel-mediated responses
- 2000 - 2001 Mechanisms responsible for MaxiK_<Ca> channel-mediated vascular relaxation
- 1998 - 1999 血管作働性物質によるマキシK_<Ca>チャネル修飾機構の分子機序と生理的意義
- 1998 - 1999 NO関連物質によるマキシK^+チャネル活性化の分子機構と生理的意義
- 1994 - 1994 血管の動力学的刺激-機能発現過程におけるチロシンキナーゼによる特異的調節機構
- 1994 - 1994 脈管系におけるバイオメカニクス反応と薬物による制御
- 1993 - 1993 筋ジストロフィーマウスを用いた循環系のメカノセンサー機構に関わる分子薬理的研究
- 1993 - 1993 血管〓縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序
- 1992 - 1993 Sutudy of vascular reactions in response to hemodynamic factors assessed by stretch activation
- 1992 - 1992 血管攣縮関与推定因子の複合刺激による相乗的血管収縮機能発現とその細胞内機序
- 1990 - 1991 Coupling mechanism of mechano-sensing and cellular reactivity in the process of stretch activation of vascular tissue.
- 1988 - 1989 Study of the stimulus-response relationship in a multi-cellular system by use of stretch-induced contractile activation of vascular tissue.
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Papers (178)：
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Keisuke Obara, Haruka Mori, Suzune Ihara, Kento Yoshioka, Yoshio Tanaka. Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 328-333
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Guanghan Ou, Akane Komura, Misaki Hojo, Rina Kato, Masahiro Ikeda, Miki Fujisawa, Keyue Xu, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka. Pharmacological study on the enhancing effects of U46619 on guinea pig urinary bladder smooth muscle contraction induced by acetylcholine and α,β-methylene ATP and the possible involvement of protein kinase C. Journal of Pharmacological Sciences. 2023
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Keisuke Obara, Mizuki Kaneko, Mio Yamashita, Ge Liu, Kento Yoshioka, Yoshio Tanaka. Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca2+ channels and store-operated Ca2+ channels. Journal of pharmacological sciences. 2023. 152. 2. 123-127
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Obara, K., Matsuoka, Y., Iwata, N., Abe, Y., Ikegami, Y., Fujii, A., Yoshioka, K., Tanaka, Y. Dimethyl Sulfoxide Enhances Acetylcholine-Induced Contractions in Rat Urinary Bladder Smooth Muscle by Inhibiting Acetylcholinesterase Activities. Biological and Pharmaceutical Bulletin. 2023. 46. 2. 354-358
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Ge Liu, Keisuke Obara, Kento Yoshioka, Yoshio Tanaka. Pharmacological Studies on the Ca2+ Influx Pathways in Platelet-Activating Factor (PAF)-Induced Mouse Urinary Bladder Smooth Muscle Contraction. Biological & pharmaceutical bulletin. 2023. 46. 7. 997-1003
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MISC (167)：
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藤井 彩乃, 小原 圭将, 八巻 史子, 田中 芳夫. 各種統合失調症治療薬のアセチルコリンエステラーゼ(AChE)活性阻害作用の検討. 応用薬理. 2018. 94. 5-6. 101-101
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鶴岡 優里, 山岸 理沙, 曽根 知世, 山崎 玖美, 茅野 大介, 椎名 俊介, 小原 圭将, 八巻 史子, 檜貝 孝慈, 田中 芳夫. イソプレナリンによるモルモット結腸縦走筋の弛緩反応にはβ1とβ3-アドレナリン受容体が関与する. 応用薬理. 2018. 94. 5-6. 115-115
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小原 圭将, 今中 智子, 福原 央香, 宇野 準二, 茅野 大介, 田中 芳夫. 雌性モルモットの近位および遠位尿道でのノルアドレナリンの収縮作用に対する各種抗うつ薬の影響. 日本薬学会年会要旨集. 2016. 136年会. 3. 68-68
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椎名 俊介, 橋本 瑛里, 小原 圭将, 茅野 大介, 田中 芳夫. ラット胸部大動脈のβ-アドレナリン受容体(β-ADR)を介した弛緩反応に関するK+チャネル分子種の薬理学的同定. 日本薬学会年会要旨集. 2016. 136年会. 3. 178-178
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Kyosuke Sato, Nanako Nishioka, Keisuke Kanai, Mika Aoki, Keisuke Obara, Daisuke Chino, Yoshio Tanaka. ISignificant roles for K+ channels and cytochrome P450 (CYP) epoxygenase metabolites in the relaxant effects of docosahexaenoic acid (DHA) on the rat thoracic aorta contracted with TXA(2) receptor (TP receptor) stimulation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 159P-159P
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Professional career (1)：
Association Membership(s) (3)：
JAPAN SOCIETY OF SMOOTH MUSCLE RESEARCH
, THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
