Research theme for competitive and other funds (9):
2021 - 2024 加齢依存的脂肪性肝疾患の病態と分子機序の解明
2020 - 2023 Elucidation of the roles of the Hippo-YAP signaling pathway in regulating cell tension in liver development and regeneration
2018 - 2021 脳腫瘍における GTP 代謝スイッチの分子機構と意義の解明
2014 - 2017 The role of myotubularins in pathogenesis of microscopic polyangiitis.
2015 - 2016 GTPエネルギー代謝に着目した癌検査及び治療技術の開発
2011 - 2012 甲状腺濾胞癌の発症におけるリン脂質代謝酵素の機能解析
2009 - 2011 イノシトールリン脂質研究に新展開をもたらすパラダイムの構築
2009 - 2010 脂質脱リン酸化酵素阻害によるリソソーム機能賦活・長寿モデルマウスの開発
2005 - 2007 真核生物におけるmRNA分解の負の制御とその抑制解除の分子機構の解明
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Papers (42):
Satoshi Kofuji, Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Yoshihisa Hirota, Aki Ogawa-Iio, Hirotaka Kanoh, Mika Sasaki, Kaori Kofuji, et al. A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochemical and biophysical research communications. 2024. 718. 149981-149981
Yoshiki Ikeda, Mindy I Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Mika Sasaki, Yoshihisa Hirota, Rajan Pragani, Min Shen, Matthew B Boxer, et al. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023. 679. 116-121
Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023. 26. 7. 107218-107218
Chiyumi Oda, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Yuto Tanaka, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, et al. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochemistry and biophysics reports. 2022. 32. 101352-101352
2014/04 - 2017/05 University of Cincinnati, OH, USA Postdoctoral Fellow
2013/12 - 2014/03 Akita University
2012/04 - 2013/11 Akita University Graduate School of Medicine
2008/08 - 2012/03 Akita University School of Medicine
2008/04 - 2008/07 The University of Tokyo Graduate School of Pharmaceutical Sciences
2005/04 - 2008/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
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Awards (1):
2021/04 - United Japanese researchers Around the world UJA Paper Award IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma
Association Membership(s) (3):
The Japanese Society of Cell Death Research
, The Pharmaceutical Society of Japan
, The Molecular Biology Society of Japan