Okuyama Kohei

オクヤマコウヘイ | Okuyama Kohei

Affiliation and department：
Job title： Postdoctoral Fellow

Research field (4)： Tumor biology , Cell biology , Tumor diagnostics and therapeutics , Surgical dentistry

Research keywords (10)： Immune checkpoint inhibition , Head and Neck Squamous Cell Carcinoma , Perineural Invasion , Myelin , Schwann cell , Cancer-associated nerve , Epithelial-mesenchymal transition , Cancer-associated fibroblast , Cancer microenvironment , Cancer Stem Cell

Research theme for competitive and other funds (7)：

2024 - 2027 頭頸部がん微小環境における腫瘍関連神経とCAFsのクロストークの解明
2023 - 2026 Cetuximab長期投与が及ぼす腫瘍細胞のpyroptosisへの影響
2021 - 2024 The predictive factor on the cancer treatment with pembrolizumab.
2021 - 2024 The prolonged cetuximab treatment effect for the dynamics of cell cytoskeleton and intracellular protein transportation in tongue squamous cell carcinoma cell.
2022 - 口腔癌発生過程における免疫寛容獲得メカニズムの解明

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Papers (50)：

Kohei Okuyama, Souichi Yanamoto. Acid-Resistant Oral Microbiome on Oral Cancer Development. JAMA Otolaryngology-Head & Neck Surgery. 2025. (Published online)
Kohei Okuyama, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto. From Wound Coverage to Functional Healing: A Narrative Review of Biomaterial Applications in Head and Neck Mucosal Defects. Head & Neck. 2025. 47. 11. 3201-3208
Kohei Okuyama, Junya Fujimoto, Souichi Yanamoto. HPV-positive HNSCC and Fc-silent PD-1 blockade: a clinical discrepancy that raises next immunological questions. Journal for ImmunoTherapy of Cancer. 2025. 13. 8. e012728-e012728
Kohei Okuyama, Souichi Yanamoto. Comment on “The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry”. Oral Oncology. 2025. 162. 107213
Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto. Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: The therapeutic barrier. Therapeutic Advances in Medical Oncology. 2025. 17. 17588359251317144

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MISC (13)：

Okuyama K., Suzuki K., Yanamoto S. Cancers | Most Viewed Papers in 2023 in the Section “Tumor Microenvironment” [https://www.mdpi.com/journal/cancers/announcements/6944]. Cancers. 2023
Kohei Okuyama, Tomofumi Naruse, Souichi Yanamoto. Tumor Microenvironment Modulation by Cetuximab and its Contribution to Subsequent Immune-Checkpoint Inhibition Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma. Journal of Oral and Maxillofacial Surgery. 2023. 81. 9. S76-S77
奥山紘平, 鳴瀬智史, 柳本惣市, 土橋宏輝, 戒田篤志, 三浦雅彦, 梅田正博. セツキシマブの長期処理がもたらす舌癌細胞遊走能の抑制は p27Kip1 依存性 G1 アレストとオートファジーを誘導する. 第39回日本口腔腫瘍学会森会•学術大会プログラム・抄録集. 2021. 29
黒嶋雄志, 小野里祐佑, 及川悠, 奥山紘平, 大迫利光, 釘本琢磨, 平井秀明, 富岡寛文, 島本裕彰, 道泰之, et al. 舌扁平上皮癌における舌リンパ節転移の臨床病理学的検討. 第39回日本口腔腫瘍学会森会•学術大会プログラム・抄録集. 2021. 12
奥山紘平, 加島義久, 平井秀明, 横川美咲, 山形優子, 道泰之, 富岡寛文, 土谷麻衣子, 栢森高, 池田通, et al. Two cases of epithelial-myoepithelial carcinoma arising in the hard palate. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2021. 39th

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Books (2)：

BIO Clinica, July 2024
New Science, Co. Ltd 2024
月刊「細胞」10月臨時増刊号
New Science, Co. Ltd 2023

Lectures and oral presentations (63)：

Chronic Opioid-Induced Mitochondrial Damage Rewires CD8+ T-Cell Metabolism and Promotes Immune Dysfunction in Cancer
(Inaugural Cancer Neuroscience Scientific Retreat at MD Anderson Cancer Center 2025)
Metabolic inhibition of BATF2 dampens type-I interferon-mediated immune sensing of cancer
(Allison Institute Second Annual Scientific Symposium 2024)
Tumor Microenvironment Modulation by Cetuximab and its Contribution to Subsequent Immune-Checkpoint Inhibition Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
(105th American Association of Oral and Maxillofacial Surgeons (AAOMS), Annual Meeting 2023)
BATF2 suppresses cancer initiation by promoting γδ T-cell-mediated immunity
(IOTN Semi-Annual SC Meeting 2023)
Resolving an Immune Tolerogenic Niche at the Earliest Phase of Oral Cancer Initiation
(AACR ANNUAL MEETING 2023 2023)

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Education (2)：

2012 - 2016 Department of Maxillofacial Surgery, Division of Maxillofacial and Neck Reconstruction, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan.
2005 - 2011 Tohoku University School of Dentistry

Professional career (1)：

Ph.D (Dentistry) (Tokyo Medical and Dental University)

Work history (14)：

2024/10 - 現在 Nagasaki University Graduate School of Biomedical Sciences Department of Skeletal Development and Regenerative Biology Adjunct Lecturer
2024/10 - 現在 Institute of Science Tokyo Department of Oral and Maxillofacial Surgical Oncology Adjunct Researcher (Part-time)
2024/06 - 現在 The University of Texas MD Anderson Cancer Center Department of Cancer Biology Postdoctoral Fellow
2022/12 - 2024/09 Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences Adjunct Lecturer
2022/07 - 2024/09 TMDU Department of Oral and Maxillofacial Surgical Oncology Adjunct Researcher (Part-time)

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Committee career (1)：

2023/01 - 現在 Oncology Letters (Spandidos Publications) : Editorial Board Member

Awards (7)：

2021/12 - AME Publishing Company Reviewer of the Month / Translational Cancer Research (TCR) /
2016/05 - 独立行政法人日本学生支援機構 (JASSO) 「特に優れた業績をあげた大学院第一種奨学生に対する返還免除制度」による第一種奨学金返還免除(全額)
2016/01 - Annual Meeting of Japanese Society of Oral Oncology Poster award
2015/10 - 60th Annual Meeting of Japanese Society of Oral and Maxillofacial Surgery Poster award
2015/05 - 15th International Congress of Radiation Research (ICRR) Young Investigators Travel Award

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Association Membership(s) (8)：

JAPANESE SOCIETY OF DENTISTRY FOR MEDICALLY COMPROMISED PATIENT , JAPANESE STOMATOLOGICAL SOCIETY , THE JAPANESE CANCER ASSOCIATION , JAPAN SOCIETY FOR HEAD AND NECK CANCER , JAPANESE SOCIETY OF ORAL ONCOLOGY , JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS , Japan Oral Oncology Group , 日本口腔診断学会

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